ArticleNucleic acids research1998
Sequence specificity of the hammerhead ribozyme revisited; the NHH rule.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Application of NMR to Large RNAs.Journal of molecular biology · 2025Review
- Hammerhead ribozymes directed against mRNA of an essential gene inhibitFrontiers in microbiology · 2025Article
- Article
- Self-cleaving ribozymes: substrate specificity and synthetic biology applications.RSC chemical biology · 2021Review
- Improved design of hammerhead ribozyme for selective digestion of target RNA through recognition of site-specific adenosine-to-inosine RNA editing.RNA (New York, N.Y.) · 2014Article
- G17-modified hammerhead ribozymes are active in vitro and in vivo.RNA (New York, N.Y.) · 2013Article
- A strategy for developing a hammerhead ribozyme for selective RNA cleavage depending on substitutional RNA editing.RNA (New York, N.Y.) · 2012Article
- Identification of hammerhead ribozymes in all domains of life reveals novel structural variations.PLoS computational biology · 2011Article
- Structure-based search reveals hammerhead ribozymes in the human microbiome.The Journal of biological chemistry · 2011Article
- Variables and strategies in development of therapeutic post-transcriptional gene silencing agents.Journal of ophthalmology · 2011Article
- pcDNA3.1(-)-mediated ribozyme targeting of HER-2 suppresses breast cancer tumor growth.Molecular biology reports · 2010Article
- New approaches for cancer treatment: antitumor drugs based on gene-targeted nucleic acids.Acta naturae · 2009Article
- Therapeutic regulation of gene expression in the inner ear using RNA interference.Advances in oto-rhino-laryngology · 2009Review
- Catalytic nucleic acid enzymes for the study and development of therapies in the central nervous system: Review Article.Gene therapy & molecular biology · 2005Article
- Article
- Design of a ribozyme targeting human telomerase reverse transcriptase and cloning of it's gene.World journal of gastroenterology · 2003Article
- A hammerhead ribozyme substrate and reporter for in vitro kinetoplastid RNA editing.RNA (New York, N.Y.) · 2002Article
- Recent advances in the elucidation of the mechanisms of action of ribozymes.Nucleic acids research · 2001Review
- Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank.Genome research · 2000Article
- In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme.Nucleic acids research · 2000Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sequence specificity of hammerhead ribozyme cleavage has been re-evaluated with respect to the NUH rule. Contrary to previous reports it was found that substrates with GAC triplets were also cleaved. This was established in three different sequence contexts. The rate of cleavage under single turnover conditions was between 3 and 7% that of cleavage 3' of GUC. Specificity of cleavage of substrates containing a central A in the cleavable triplet can be described as NAH, where N can be any nucleotide and H any nucleotide but G. As cleavage 3' of NCH triplets has recently been described, the NUH rule can be reformulated to NHH.
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