ArticleClinical and experimental immunology1998
Autoimmunity to tropomyosin isoforms in ulcerative colitis (UC) patients and unaffected relatives.
Article in Clinical and experimental immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 41 citations in OpenAlex.
- The Low-Abundance Plasma Proteome Reveals Differentially Abundant Proteins Associated with Breast Implant Capsular Contracture: A Pilot Study.Proteomes · 2024Article
- Endometriosis and inflammatory immune responses: Indian experience.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Review
- Low Level Antibodies Against Alpha-Tropomyosin Are Associated With Increased Risk of Coronary Heart Disease.Frontiers in pharmacology · 2020Article
- Proinflammatory progranulin antibodies in inflammatory bowel diseases.Digestive diseases and sciences · 2014Article
- Coherent somatic mutation in autoimmune disease.PloS one · 2014Review
- Autoantibodies in primary sclerosing cholangitis.World journal of gastroenterology · 2008Review
- Alpha tropomyosin as a self-antigen in patients with Behçet's disease.Clinical and experimental immunology · 2005Article
- Autoimmunity in ulcerative colitis (UC): a predominant colonic mucosal B cell response against human tropomyosin isoform 5.Clinical and experimental immunology · 2000Article
- Article
- Externalization of tropomyosin isoform 5 in colon epithelial cells.Clinical and experimental immunology · 1999Article
- Relationship of extraintestinal involvements in inflammatory bowel disease: new insights into autoimmune pathogenesis.Digestive diseases and sciences · 1999Review
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Autoimmunity to cytoskeletal protein tropomyosin (TM) has been demonstrated in UC. However, the TM isoforms involved in this IgG-mediated autoimmune response in UC and the possible presence of serum IgG antibodies against TM (hTMs IgG) in unaffected UC relatives are unknown. The aim of this study was to investigate the human TM (hTM) isoforms recognized by serum IgG from UC and to explore whether hTM IgG antibodies are present in healthy UC relatives. We studied 33 UC patients with 58 unaffected relatives, 31 Crohn's disease (CD) patients with 31 unaffected relatives and 20 controls (C). Serum IgG against four recombinant hTM isoforms (hTM1, 2, 3, 5) were tested by ELISA. p-ANCA were tested by ELISA and immunofluorescence. Serum hTM1 and hTM5 IgG were higher in UC patients than in CD and C (P<0.005). Among UC patients 52% were seropositive for hTM1 and 64% for hTM5 (P<0.001 versus CD and C). In UC, hTM5 IgG were higher in p-ANCA+ than in ANCA- patients (P=0.04). In UC relatives hTM1 IgG were higher than in CD relatives and C (P<0.01). UC relatives were more frequently seropositive for hTM1 than hTM5 IgG (P=0.001). while probands were more frequently seropositive for hTM5 IgG (P=0.008). We conclude that autoimmunity to hTMI and hTM5 is a feature of UC, while hTM1 IgG differentiate UC relatives from controls. A genetic susceptibility to immune recognition of hTM isoforms in UC is suggested.
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