ArticleInfection
An analysis of interleukin-8, interleukin-6 and C-reactive protein serum concentrations to predict fever, gram-negative bacteremia and complicated infection in neutropenic cancer patients.
Article in Infection. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 104 citations in OpenAlex.
- Lipopolysaccharide-binding protein: a possible diagnostic marker for Gram-negative bacteremia in neutropenic cancer patients.Intensive care medicine · 2003Trial
- Clinical prediction rule for bacteremia with pyelonephritis and hospitalization judgment: chi-square automatic interaction detector (CHAID) decision tree analysis model.The Journal of international medical research · 2022Article
- Procalcitonin and C-Reactive Protein As Markers of Bacteremia in Patients With Febrile Neutropenia Who Receive Chemotherapy for Acute Leukemia: A Prospective Study From Nepal.Journal of global oncology · 2019Article
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- Inflammatory molecules expression pattern for identifying pathogen species in febrile patient serum.Experimental and therapeutic medicine · 2016Article
- Intensive serial biomarker profiling for the prediction of neutropenic Fever in patients with hematologic malignancies undergoing chemotherapy: a pilot study.Hematology reports · 2014Article
- Biomarkers for sepsis: a review with special attention to India.BioMed research international · 2014Review
- Procalcitonin and C-reactive protein in the diagnosis and prediction of spontaneous bacterial peritonitis associated with chronic severe hepatitis B.Annals of laboratory medicine · 2013Article
- Diagnostic value of lipopolysaccharide-binding protein and procalcitonin for sepsis diagnosis in forensic pathology.International journal of legal medicine · 2013Article
- Use of inflammatory molecules to predict the occurrence of fever in onco-hematological patients with neutropenia.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Observational
- Inflammatory cytokine measurement quickly discriminates gram-negative from gram-positive bacteremia in pediatric hematology/oncology patients with septic shock.Intensive care medicine · 2013Article
- New approaches to sepsis: molecular diagnostics and biomarkers.Clinical microbiology reviews · 2012Article
- Cytokine screening identifies NICU patients with Gram-negative bacteremia.Pediatric research · 2012Article
- Predictive factors of poor prognosis in cancer patients with chemotherapy-induced febrile neutropenia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2011Article
- Systemic inflammatory response associated with distant metastasis of T1 or T2 colorectal cancer.Digestive diseases and sciences · 2010Article
- Cytokine concentrations are not predictive of bacteremia in febrile neutropenic patients.Medical oncology (Northwood, London, England) · 2009Article
- Risk factors for negative blood cultures in adult medical inpatients--a retrospective analysis.BMC infectious diseases · 2008Article
- Bacteraemia coincides with low citrulline concentrations after high-dose melphalan in autologous HSCT recipients.Bone marrow transplantation · 2008Article
- Characteristics of febrile patients with normal white blood cell counts and high C-reactive protein levels in an emergency department.The Kaohsiung journal of medical sciences · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A prospective study was performed to assess the potential value of interleukin (IL)-8, IL-6, and C-reactive protein (CRP) serum levels to predict fever, gram-negative bacteremia and complicated infection in neutropenic patients with cancer. Serum samples were obtained three times a week during 208 neutropenic episodes following cytotoxic chemotherapy. Fever of any cause developed during 104 out of 191 evaluable episodes. Serum levels of neither cytokine nor CRP were predictive of fever within more than 24 h before its onset. Unlike CRP, both IL-6 and IL-8 serum levels were significantly different between microbiologically documented infections and unexplained fevers. The highest values of IL-6 and IL-8 were observed in episodes of gram-negative bacteremia. Using receiver-operating-characteristic curves, the analysis of cytokine levels measured around the onset of fever indicated that IL-8 is potentially useful for predicting gram-negative bacteremia, with a high negative predictive value of > 90% and a moderate positive predictive value of 50% (sensitivity, 70%; specificity, 91%). In patients with persistent fever, predictions of further clinical complications, defined as prolonged fever of more than 7 days' duration, pneumonia, shock and/or death due to infection, were best predicted by IL-6. With an IL-6 cutoff value of 250 pg/ml in samples obtained 8 to 32 h after onset of fever, the positive predictive value was 92%, the negative predictive value 91% (sensitivity, 85%; specificity, 95%). The positive predictive value of IL-6 in samples obtained another 24 h later from patients still febrile remained > 90%, but the negative predictive value dropped to 47%. In any of the analyses, the predictive values of CRP levels were poor and inferior to either cytokine. These findings may have clinical value in identifying subgroups of patients requiring different therapeutic approaches.
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