ArticleGenes & development1998
Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes.
Article in Genes & development, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 109 citations in OpenAlex.
- Meiosis initiation: a story of two sexes in all creatures great and small.The Biochemical journal · 2021Review
- Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB).Biology of reproduction · 2019Review
- Requirement of the 3'-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development.PLoS genetics · 2018Article
- Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice.Endocrinology · 2016Article
- RNA transport and long-term memory storage.RNA biology · 2013Article
- Cyclin B1 mRNA translation is temporally controlled through formation and disassembly of RNA granules.The Journal of cell biology · 2013Article
- Article
- Article
- Proteasomal activity is required to initiate and to sustain translational activation of messenger RNA encoding the stem-loop-binding protein during meiotic maturation in mice.Biology of reproduction · 2010Article
- Dcp1-bodies in mouse oocytes.Molecular biology of the cell · 2009Article
- Neuronal expression of splice variants of "glial" glutamate transporters in brains afflicted by Alzheimer's disease: unmasking an intrinsic neuronal property.Neurochemical research · 2009Article
- Genomic RNA profiling and the programme controlling preimplantation mammalian development.Molecular human reproduction · 2008Article
- Identification and characterization of human embryonic poly(A) binding protein (EPAB).Molecular human reproduction · 2008Article
- Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation.Molecular reproduction and development · 2008Article
- Isolation of the human ePAB and ePABP2 cDNAs and analysis of the expression patterns.Journal of assisted reproduction and genetics · 2008Article
- Selective degradation of transcripts during meiotic maturation of mouse oocytes.Developmental biology · 2007Article
- The stem-loop binding protein regulates translation of histone mRNA during mammalian oogenesis.Developmental biology · 2005Article
- An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Cytoplasmic polyadenylation element (CPE)- and CPE-binding protein (CPEB)-independent mechanisms regulate early class maternal mRNA translational activation in Xenopus oocytes.The Journal of biological chemistry · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms responsible for translational silencing of certain mRNAs in growing oocytes, and for their awakening during meiotic maturation, are not completely elucidated. We show that binding of a approximately 80-kD protein to a UA-rich element in the 3' UTR of tissue-type plasminogen activator mRNA, a mouse oocyte mRNA that is translated during meiotic maturation, silences the mRNA in primary oocytes. Translation can be triggered by injecting a competitor transcript that displaces this silencing factor, without elongation of a pre-existing short poly(A) tail, the presence of which is mandatory. During meiotic maturation, cytoplasmic polyadenylation is necessary to maintain a poly(A) tail, but the determining event for translational activation appears to be the modification or displacement of the silencing factor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.