ArticleInfection and immunity1998
Characterization of an acidic-pH-inducible stress protein (hsp70), a putative sulfatide binding adhesin, from Helicobacter pylori.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 79 citations in OpenAlex.
- Adaptation mechanisms of ANAMMOX bacteria to extreme environments.Archives of microbiology · 2026Review
- Bacillus megaterium adapts to acid stress condition through a network of genes: Insight from a genome-wide transcriptome analysis.Scientific reports · 2018Article
- The Interplay between Two Transcriptional Repressors and Chaperones OrchestratesInternational journal of molecular sciences · 2018Review
- Integrative approach for the analysis of the proteome-wide response to bismuth drugs inChemical science · 2017Article
- Adhesion Properties of Lactic Acid Bacteria on Intestinal Mucin.Microorganisms · 2016Review
- Characterization and function analysis of Hsp60 and Hsp10 under different acute stresses in black tiger shrimp, Penaeus monodon.Cell stress & chaperones · 2016Article
- Sulfatide-Hsp70 interaction promotes Hsp70 clustering and stabilizes binding to unfolded protein.Biomolecules · 2015Article
- Identification and characterization of sulfated carbohydrate-binding protein from Lactobacillus reuteri.PloS one · 2013Article
- Helicobacter pylori urease activity is influenced by ferric uptake regulator.Yonsei medical journal · 2010Article
- Sulfatide recognition by colonization factor antigen CS6 from enterotoxigenic Escherichia coli.PloS one · 2009Article
- Immunization against Clostridium perfringens cells elicits protection against Clostridium tetani in mouse model: identification of cross-reactive proteins using proteomic methodologies.BMC microbiology · 2008Article
- The changes of proteomes components of Helicobacter pylori in response to acid stress without urea.Journal of microbiology (Seoul, Korea) · 2008Article
- Identification of Campylobacter jejuni genes involved in the response to acidic pH and stomach transit.Applied and environmental microbiology · 2008Article
- Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infection.Infection and immunity · 2006Review
- Pathogenesis of Helicobacter pylori infection.Clinical microbiology reviews · 2006Review
- Acid-responsive gene induction of ammonia-producing enzymes in Helicobacter pylori is mediated via a metal-responsive repressor cascade.Infection and immunity · 2004Article
- Growth phase-dependent response of Helicobacter pylori to iron starvation.Infection and immunity · 2003Article
- Acid-adaptive genes of Helicobacter pylori.Infection and immunity · 2003Article
- Binding of Actinobacillus pleuropneumoniae to phosphatidylethanolamine.Infection and immunity · 2003Article
- Development of an interleukin-12-deficient mouse model that is permissive for colonization by a motile KE26695 strain of Helicobacter pylori.Infection and immunity · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in vitro glycolipid binding specificity of the gastric pathogen Helicobacter pylori is altered to include sulfated glycolipids (sulfatides) following brief exposure of the organism to acid pH typical of the stomach. This change is prevented by anti-hsp70 antibodies, suggesting that hsp70 may be a stress-induced surface adhesin, mediating sulfatide recognition. To facilitate investigation of the role of hsp70 in attachment, we have cloned and sequenced the H. pylori hsp70 gene (dnaK). The hsp70 gene was identified by probing a cosmid DNA library made from H. pylori 439 with a PCR amplicon generated with oligonucleotides synthesized to highly conserved regions of dnaK. The 1.9-kb H. pylori hsp70 gene encodes a product of 616 amino acids. Primer extension analysis revealed a single transcription start site, while Northern blot analysis established that hsp70 was preferentially induced by low pH rather than by heat shock. The ability of H. pylori to alter its glycolipid binding specificity following exposure to low pH by upregulating hsp70 and by expressing hsp70 on the bacterial surface may provide a survival advantage during periods of high acid stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.