ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 80 citations in OpenAlex.
- Article
- Specialized mechanoreceptor systems in rodent glabrous skin.The Journal of physiology · 2018Article
- Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused byProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genetic Tracing of CaFrontiers in molecular neuroscience · 2017Article
- KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors.The Journal of biological chemistry · 2016Article
- Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn.Neuron · 2014Article
- The sensory neurons of touch.Neuron · 2013Review
- Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation.PloS one · 2013Article
- Neurotrophin-4 regulates the survival of gustatory neurons earlier in development using a different mechanism than brain-derived neurotrophic factor.Developmental biology · 2012Article
- Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor.Development (Cambridge, England) · 2012Article
- Article
- Perspectives on: information and coding in mammalian sensory physiology: probing mammalian touch transduction.The Journal of general physiology · 2011Article
- Impaired sensory nerve function and axon morphology in mice with diabetic neuropathy.Journal of neurophysiology · 2011Article
- Peripheral somatosensation: a touch of genetics.Current opinion in genetics & development · 2011Review
- The cell biology of touch.The Journal of cell biology · 2010Review
- Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The dark side of the NGF family: neurotrophins in neoplasias.Brain pathology (Zurich, Switzerland) · 2006Review
- Overexpression of neurotrophin 4 in skin enhances myelinated sensory endings but does not influence sensory neuron number.The Journal of comparative neurology · 2006Article
- Exploring developmental, functional, and evolutionary aspects of amphioxus sensory cells.International journal of biological sciences · 2006Review
- From neurotrophins to immunotrophins. NGF 2002: The 7th international conference on NGF and related molecules.EMBO reports · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotrophin-4 (NT4) is the most recently discovered neurotrophic factor in mammals and, functionally, the least well understood. Here, we used mice that lack NT4 to determine whether NT4 is required for the survival of functionally identified subclasses of cutaneous sensory neurons. By using three independent methods of histological and electrophysiological analysis, we show that NT4 is specifically required for the survival of down hair (D-hair) receptors that innervate a subpopulation of hair follicles. All other functionally distinct types of afferents neurons innervating hairy skin were not affected in their survival or in their function. Previous studies have shown that BDNF is required for the mechanical sensitivity of slowly adapting (SA) mechanoreceptors but not for the postnatal survival of myelinated cutaneous afferent fibers. In contrast, the receptive properties of SA mechanoreceptors were not impaired in animals lacking NT4. Consequently, these data show that the two trkB ligands, NT4 and BDNF, have distinct and nonoverlapping roles in supporting cutaneous sensory neurons. Whereas NT4 is required for the survival of D-hair receptors, BDNF supports the mechanical function of SA fibers.
Indexed as
Identifiers
9712673PMC6792951W2106012469What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.