ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Retroviral transfer of antisense integrin alpha6 or alpha8 sequences results in laminar redistribution or clonal cell death in developing brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
- Misexpression of ephrin-B2 disrupts laminar patterning in chick optic tectum.Brain structure & function · 2025Article
- Ion channels in neurodevelopment: lessons from the Integrin-KCNB1 channel complex.Neural regeneration research · 2023Article
- Altering Cell-Cell Interaction in Prenatal Alcohol Exposure Models: Insight on Cell-Adhesion Molecules During Brain Development.Frontiers in molecular neuroscience · 2021Review
- Neocortical neurogenesis and neuronal migration.Wiley interdisciplinary reviews. Developmental biology · 2013Review
- HLA class I: an unexpected role in integrin β4 signaling in endothelial cells.Human immunology · 2012Review
- Serotonergic neurons migrate radially through the neuroepithelium by dynamin-mediated somal translocation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Stimulation of glioma cell motility by expression, proteolysis, and release of the L1 neural cell recognition molecule.Cancer cell international · 2009Article
- Chondroitin sulfate proteoglycans regulate the growth, differentiation and migration of multipotent neural precursor cells through the integrin signaling pathway.BMC neuroscience · 2009Article
- Integrin beta 4 in neural cells.Neuromolecular medicine · 2008Review
- Article
- Human and rat glioma growth, invasion, and vascularization in a novel chick embryo brain tumor model.Clinical & experimental metastasis · 2005Article
- Integrin subunit gene expression is regionally differentiated in adult brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Tensegrin in context: Dual role of α8 integrin in the migration of different cell types.Cell adhesion & migrationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess the roles of two integrin alpha subunits (alpha6 and alpha8) in the developing chicken optic tectum, progenitors were infected with retroviral vectors that contained the marker gene lacZ plus antisense sequences from either the alpha6 or alpha8 integrin subunit cDNAs. On embryonic day 3 (E3), the vector was injected into tectal ventricles of chicken embryos. On E6, E7.5, E9, or later, chicken embryos were killed, and optic tecta were dissected and processed for histochemical detection of lacZ-positive cells. The antisense-bearing cell clones (descendants of a single infected progenitor) were analyzed for proliferation and migration patterns and were compared with lacZ-only vector-infected control clones. At E6, both alpha6 and alpha8 integrin antisense-containing cell clones were similar to controls. At E7.5, integrin alpha8 antisense-containing clones exhibited a cell number reduction in upper laminae (intermediate zone and tectal plate), and at E9, they exhibited a reduction in the ventricular zone as well. Integrin alpha6 antisense-containing cell clones exhibited no difference in total cell number at E9 but had a net laminar redistribution of more cells in the ventricular zone and less cells in the tectal plate. Our data show that different integrins play different roles during brain development: alpha6 integrin is essential for migration of tectal cells into specific laminae, and alpha8 integrin is essential for the survival of optic tectum cells. Also alpha8 integrin-substrate interactions may suppress early programmed cell death in premigratory and migratory neuroblasts.
Indexed as
Identifiers
9712662PMC6792989W1918581737What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.