ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
A functional interaction between the neuronal adhesion molecules TAG-1 and F3 modulates neurite outgrowth and fasciculation of cerebellar granule cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 63 citations in OpenAlex.
- TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation.Cell reports · 2020Article
- Selective Axonal Expression of the Kv1 Channel Complex in Pre-myelinated GABAergic Hippocampal Neurons.Frontiers in cellular neuroscience · 2019Article
- A novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism.Translational psychiatry · 2014Article
- Mutation of the BiP/GRP78 gene causes axon outgrowth and fasciculation defects in the thalamocortical connections of the mammalian forebrain.The Journal of comparative neurology · 2013Article
- Expanding the Ig superfamily code for laminar specificity in retina: expression and role of contactins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The effects of Tag-1 on the maturation of mouse cerebellar granule neurons.Cellular and molecular neurobiology · 2011Article
- F3/contactin and TAG1 play antagonistic roles in the regulation of sonic hedgehog-induced cerebellar granule neuron progenitor proliferation.Development (Cambridge, England) · 2011Article
- A spontaneous mutation in contactin 1 in the mouse.PloS one · 2011Article
- Axonin-1/TAG-1 is required for pathfinding of granule cell axons in the developing cerebellum.Neural development · 2008Article
- Contactin 1 knockdown in the hindbrain induces abnormal development of the trigeminal sensory nerve in Xenopus embryos.Development genes and evolution · 2007Article
- The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction.Protein science : a publication of the Protein Society · 2007Article
- Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers.The Journal of cell biology · 2003Article
- Tenascin-C promotes neurite outgrowth of embryonic hippocampal neurons through the alternatively spliced fibronectin type III BD domains via activation of the cell adhesion molecule F3/contactin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- The glycosylphosphatidyl inositol-anchored adhesion molecule F3/contactin is required for surface transport of paranodin/contactin-associated protein (caspr).The Journal of cell biology · 2000Article
- Neurotrimin mediates bifunctional effects on neurite outgrowth via homophilic and heterophilic interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- The mouse F3/contactin glycoprotein: structural features, functional properties and developmental significance of its regulated expression.Cell adhesion & migrationReview
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
F3 and TAG-1 are two closely related adhesion glycoproteins of the Ig superfamily that are both expressed by the axons of cerebellar granule cells. In an in vitro system in which cerebellar granule cells were cultured on monolayers of transfected Chinese hamster ovary (CHO) cells, we show that F3 and TAG-1 interact functionally. F3 transfectants have been shown to inhibit outgrowth and induce fasciculation of granule cell neurites. By contrast TAG-1 transfectants have no effect on these events. However, when TAG-1 is coexpressed with F3, the inhibitory effect of F3 is blocked. Two possible mechanisms may account for this functional interaction: (1) either TAG-1 and F3 compete for the same neuronal receptor, and in favor of this we observed that binding sites for microspheres conjugated with F3 and TAG-1 are colocalized on the granule cell growth cones, (2) or alternatively, F3 and TAG-1 associate in a multimolecular complex after their binding to independent receptors. Extensive co-clustering of F3 with TAG-1 can in fact be achieved by anti-TAG-1 antibody-mediated cross-linking in double-transfected CHO cells. Moreover, F3 coimmunoprecipitates with TAG-1 in Triton X-100-insoluble microdomains purified from newborn brain. These data strongly suggest that F3 and TAG-1 may associate under physiological conditions to modulate neurite outgrowth and fasciculation of the cerebellar granule cells.
Indexed as
Identifiers
9712656PMC6792965W1559041966What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.