ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Dendrodendritic inhibition in the olfactory bulb is driven by NMDA receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers.
What it found
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Who cites it
163 citing papers in PubMed, 342 citations in OpenAlex.
- Early and Late Phases of Sensory-Evoked Olfactory Bulb Inhibition Are Mediated by Parallel Local Circuits: Attenuation of Fast Tufted Cell Axo-dendritic Inputs to Granule Cells by Adenosine A1 Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- D2 receptor activation modulates NMDA receptor antagonist-enhanced high-frequency oscillations in the olfactory bulb of freely moving rats.Psychopharmacology · 2025Article
- Calretinin-Expressing Neurons in the Basal Forebrain Specifically Contact Granule Cells in the Olfactory Bulb and Modulate Odor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Review
- Chronic exposure to MK-801 leads to olfactory deficits and reduced neurogenesis in the olfactory bulbs of adult male mice.Frontiers in behavioral neuroscience · 2024Article
- Activation of arginine vasopressin receptor 1a reduces inhibitory synaptic currents at reciprocal synapses in the mouse accessory olfactory bulb.Frontiers in cellular neuroscience · 2024Article
- Voltage imaging in the olfactory bulb using transgenic mouse lines expressing the genetically encoded voltage indicator ArcLight.Scientific reports · 2022Article
- Connectivity and dynamics in the olfactory bulb.PLoS computational biology · 2022Article
- αFrontiers in cellular neuroscience · 2022Article
- Cortical feedback and gating in odor discrimination and generalization.PLoS computational biology · 2021Article
- Changes in pairwise correlations during running reshape global network state in the main olfactory bulb.Journal of neurophysiology · 2021Article
- Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Olfactory bulb granule cells: specialized to link coactive glomerular columns for percept generation and discrimination of odors.Cell and tissue research · 2021Article
- Src/CK2/PTEN-Mediated GluN2B and CREB Dephosphorylations Regulate the Responsiveness to AMPA Receptor Antagonists in Chronic Epilepsy Rats.International journal of molecular sciences · 2020Article
- Activation of Granule Cell Interneurons by Two Divergent Local Circuit Pathways in the Rat Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Dendritic integration in olfactory bulb granule cells upon simultaneous multispine activation: Low thresholds for nonlocal spiking activity.PLoS biology · 2020Article
- Predicting brain organization with a computational model: 50-year perspective on lateral inhibition and oscillatory gating by dendrodendritic synapses.Journal of neurophysiology · 2020Review
- Paradoxically Sparse Chemosensory Tuning in Broadly Integrating External Granule Cells in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
103 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
At many central excitatory synapses, AMPA receptors relay the electrical signal, whereas activation of NMDA receptors is conditional and serves a modulatory function. We show here quite a different role for NMDA receptors at dendrodendritic synapses between mitral and granule cells in the rat olfactory bulb. In whole-cell patch-clamp recordings in bulb slices, stimulation of mitral cells elicited slowly decaying, GABAA receptor-mediated reciprocal IPSCs that reflected prolonged GABA release from granule cells. Although granule cells had a normal complement of AMPA and NMDA receptors, the IPSC was completely blocked by the NMDA receptor antagonist D,L-AP-5, suggesting that NMDA receptor activation is an absolute requirement for dendrodendritic inhibition. The AMPA receptor antagonist 1,2,3,4-tetrahydro-6-nitro-2, 3-dioxobenzo[f]quinoxaline-7-sulfonamide (NBQX) had no effect on IPSCs in the absence of extracellular magnesium but modestly reduced IPSCs in 1 mM magnesium, indicating that the primary effect of the AMPA receptor-mediated depolarization was to facilitate the unblocking of NMDA receptors. Granule cell voltage recordings indicated that effective spike stimulation in granule cells depended on the slow NMDA receptor kinetics. Granule cells also showed a pronounced delay between synaptic stimulation and action potential generation, suggesting that their intrinsic membrane properties underlie the ineffectiveness of brief AMPA receptor-mediated EPSPs. NMDA receptors also seem to have a central role in dendrodendritic inhibition in vivo, because intraperitoneal dizocilpine maleate (MK-801) injection in young adult rats resulted in disinhibition of mitral cells as measured by the generation of c-fos mRNA. The unique dependence of dendrodendritic inhibition on slow EPSPs generated by NMDA receptors suggests that olfactory information processing depends on long-lasting reciprocal and lateral inhibition.
Indexed as
Identifiers
9712650PMC6792983W2154138317What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.