ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Oxidation regulates cloned neuronal voltage-dependent Ca2+ channels expressed in Xenopus oocytes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
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- Transient and Sustained Ganglion Cell Light Responses Are Differentially Modulated by Intrinsically Produced Reactive Oxygen Species Acting upon Specific Voltage-Gated NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Oxidation of active cysteines mediates protein aggregation of S10R, the cataract-associated mutant of mouse GammaB-crystallin.Proteins · 2022Article
- Calcium Dyshomeostasis and Lysosomal CaCells · 2019Review
- In Vivo Effects of Methionine Sulfoxide Reductase Deficiency inAntioxidants (Basel, Switzerland) · 2018Article
- HAmerican journal of physiology. Cell physiology · 2017Article
- Dual Oxidase 2 (Duox2) Regulates Pannexin 1-mediated ATP Release in Primary Human Airway Epithelial Cells via Changes in Intracellular pH and Not H2O2 Production.The Journal of biological chemistry · 2016Article
- Hydrogen peroxide modulates synaptic transmission in ventral horn neurons of the rat spinal cord.The Journal of physiology · 2016Article
- Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice.Free radical biology & medicine · 2015Article
- Glutathionylation of the L-type Ca2+ channel in oxidative stress-induced pathology of the heart.International journal of molecular sciences · 2014Review
- Diet-dependent modulation of gastro-oesphageal vagal afferent mechanosensitivity by endogenous nitric oxide.The Journal of physiology · 2014Article
- An intracellular redox sensor for reactive oxygen species at the M3-M4 linker of GABAA ρ1 receptors.British journal of pharmacology · 2014Article
- Pathophysiologically relevant levels of hydrogen peroxide induce glutamate-independent neurodegeneration that involves activation of transient receptor potential melastatin 7 channels.Antioxidants & redox signaling · 2011Article
- Role of oxidant scavengers in the prevention of Ca²+ homeostasis disorders.Molecules (Basel, Switzerland) · 2010Review
- Sources and targets of reactive oxygen species in synaptic plasticity and memory.Antioxidants & redox signaling · 2007Review
- Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits.The Journal of general physiology · 2004Article
- NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Hydrogen peroxide modulation of synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Exacerbated responses to oxidative stress by an Na(+) load in isolated nerve terminals: the role of ATP depletion and rise of [Ca(2+)](i).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Functional modifications of neuronal P/Q-type voltage-dependent Ca2+ channels expressed in Xenopus oocytes by oxidation were examined electrophysiologically. Oxidation by external H2O2 enhanced the whole-oocyte currents through the Ca2+ channels composed of the alpha1A, alpha2/delta, and beta3 subunits at negative voltages (<0 mV) without markedly affecting the currents at more positive voltages. Single-channel analysis showed that oxidation accelerates the overall channel opening process. The effect of H2O2 to enhance the Ca2+ channel activity did not require heterologous expression of the alpha2/delta subunit, and it was not mimicked by a cysteine-specific oxidizing agent. The results suggest that oxidative stress may regulate the activity of neuronal Ca2+ channels and that regulation by oxidation may be important in some clinical situations, such as in reperfusion injury after ischemic episodes.
Indexed as
Identifiers
9712645PMC6792958W1823743265What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.