ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Inwardly rectifying potassium (IRK) currents are correlated with IRK subunit expression in rat nucleus accumbens medium spiny neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 98 citations in OpenAlex.
- Distinct electrophysiology and dopaminergic modulation of medium spiny neurons across divisions of the tail striatum and the dorsolateral striatum.Experimental physiology · 2026Article
- Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum.bioRxiv : the preprint server for biology · 2026Article
- Enhancement of calcium responses by KJournal of biosciences · 2026Article
- Distinctive physiology of molecularly identified medium spiny neurons in the macaque putamen.Cell reports · 2024Article
- Sex differences in membrane properties and cellular excitability of dopamine D1 receptor-expressing neurons within the shell of the nucleus accumbens of pre- and mid-adolescent mice.Biology of sex differences · 2024Article
- FOXP1 regulates the development of excitatory synaptic inputs onto striatal neurons and induces phenotypic reversal with reinstatement.Science advances · 2024Article
- Regional heterogeneity in the membrane properties of mouse striatal neurons.Frontiers in cellular neuroscience · 2024Article
- The Basal Ganglia Downstream Control of Action - An Evolutionarily Conserved Strategy.Current neuropharmacology · 2024Review
- Article
- FireMaster® 550 (FM 550) exposure during the perinatal period impacts partner preference behavior and nucleus accumbens core medium spiny neuron electrophysiology in adult male and female prairie voles, Microtus ochrogaster.Hormones and behavior · 2021Article
- FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents.Molecular psychiatry · 2021Article
- The estrous cycle modulates rat caudate-putamen medium spiny neuron physiology.The European journal of neuroscience · 2020Article
- Eating "junk food" has opposite effects on intrinsic excitability of nucleus accumbens core neurons in obesity-susceptible versus -resistant rats.Journal of neurophysiology · 2019Article
- Electrophysiological properties of medium spiny neurons in the nucleus accumbens core of prepubertal male and female Drd1a-tdTomato line 6 BAC transgenic mice.Journal of neurophysiology · 2018Article
- Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period.Neuron · 2018Article
- Haloperidol Selectively Remodels Striatal Indirect Pathway Circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Altered enhancer transcription underlies Huntington's disease striatal transcriptional signature.Scientific reports · 2017Article
- Neonatal Masculinization Blocks Increased Excitatory Synaptic Input in Female Rat Nucleus Accumbens Core.Endocrinology · 2016Article
- A computer-based quantitative systems pharmacology model of negative symptoms in schizophrenia: exploring glycine modulation of excitation-inhibition balance.Frontiers in pharmacology · 2014Article
- Quantitative systems pharmacology as an extension of PK/PD modeling in CNS research and development.Journal of pharmacokinetics and pharmacodynamics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Inwardly rectifying K+ (IRK) channels are critical for shaping cell excitability. Whole-cell patch-clamp and single-cell RT-PCR techniques were used to characterize the inwardly rectifying K+ currents found in projection neurons of the rat nucleus accumbens. Inwardly rectifying currents were highly selective for K+ and blocked by low millimolar concentrations of Cs+ or Ba2+. In a subset of neurons, the inwardly rectifying current appeared to inactivate at hyperpolarized membrane potentials. In an attempt to identify this subset, neurons were profiled using single-cell RT-PCR. Neurons expressing substance P mRNA exhibited noninactivating inward rectifier currents, whereas neurons expressing enkephalin mRNA exhibited inactivating inward rectifier currents. The inactivation of the inward rectifier was correlated with the expression of IRK1 mRNA. These results demonstrate a clear physiological difference in the properties of medium spiny neurons and suggest that this difference could influence active state transitions driven by cortical and hippocampal excitatory input.
Indexed as
Identifiers
9712637PMC6792959W1619741950What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.