ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
A depolarizing chloride current contributes to chemoelectrical transduction in olfactory sensory neurons in situ.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 142 citations in OpenAlex.
- Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans.Nature communications · 2025Article
- Paired and solitary ionocytes in the zebrafish olfactory epithelium.Chemical senses · 2025Article
- Displacement of extracellular chloride by immobile anionic constituents of the brain's extracellular matrix.The Journal of physiology · 2025Article
- Chelating chloride using binuclear lanthanide complexes in water.Chemical science · 2023Article
- Paradoxical electro-olfactogram responses in TMEM16B knock-out mice.Chemical senses · 2023Article
- Electrophysiological responses to conspecific odorants in Xenopus laevis show potential for chemical signaling.PloS one · 2022Article
- The design and evolution of fluorescent protein-based sensors for monoatomic ions in biology.Protein engineering, design & selection : PEDS · 2021Review
- The cyclic AMP signaling pathway in the rodent main olfactory system.Cell and tissue research · 2021Review
- Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters.Frontiers in physiology · 2020Review
- Identification of mNeonGreen as a pH-Dependent, Turn-On Fluorescent Protein Sensor for Chloride.Chembiochem : a European journal of chemical biology · 2019Article
- TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium.The Journal of general physiology · 2019Article
- CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Discovery and Characterization of a Naturally Occurring, Turn-On Yellow Fluorescent Protein Sensor for Chloride.Biochemistry · 2019Article
- Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons.Scientific reports · 2018Article
- The long tale of the calcium activated ClChannels (Austin, Tex.) · 2017Review
- Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.Chemical senses · 2016Article
- The Ca2+-activated Cl- channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons.The Journal of general physiology · 2016Article
- Intracellular chloride concentration of the mouse vomeronasal neuron.BMC neuroscience · 2015Article
- Calcium-activated chloride channels in the apical region of mouse vomeronasal sensory neurons.The Journal of general physiology · 2012Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent biophysical investigations of vertebrate olfactory signal transduction have revealed that Ca2+-gated Cl- channels are activated during odorant detection in the chemosensory membrane of olfactory sensory neurons (OSNs). To understand the role of these channels in chemoelectrical signal transduction, it is necessary to know the Cl--equilibrium potential that determines direction and size of Cl- fluxes across the chemosensory membrane. We have measured Cl-, Na+, and K+ concentrations in ultrathin cryosections of rat olfactory epithelium, as well as relative element contents in isolated microsamples of olfactory mucus, using energy-dispersive x-ray microanalysis. Determination of the Cl- concentrations in dendritic knobs and olfactory mucus yielded an estimate of the Cl--equilibrium potential ECl in situ. With Cl- concentrations of 69 mM in dendritic knobs and 55 mM in olfactory mucus, we obtained an ECl value of +6 +/- 12 mV. This indicates that Ca2+-gated Cl- channels in olfactory cilia conduct inward currents in vivo carried by Cl- efflux into the mucus. Our results show that rat OSNs are among the few known types of neurons that maintain an elevated level of cytosolic Cl-. In these cells, activation of Cl- channels leads to depolarization of the membrane voltage and can induce electrical excitation. The depolarizing Cl- current in mammalian OSNs appears to contribute a major fraction to the receptor current and may sustain olfactory function in sweet-water animals.
Indexed as
Identifiers
9712634PMC6792953W2135449280What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.