ArticleMolecular and cellular biology1998
Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 125 citations in OpenAlex.
- Molecular antagonism between X-chromosome and autosome signals determines nematode sex.Genes & development · 2013Article
- Emerging roles of the corepressors NCoR1 and SMRT in homeostasis.Genes & development · 2013Review
- Tzfp represses the androgen receptor in mouse testis.PloS one · 2013Article
- Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation.The Journal of biological chemistry · 2011Article
- Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation.Molecular and cellular endocrinology · 2011Article
- A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription.The Journal of biological chemistry · 2010Article
- A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, serves as a sensor for transcriptional regulation.Molecular cancer research : MCR · 2010Article
- Article
- Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing.Molecular endocrinology (Baltimore, Md.) · 2007Article
- TBLR1 regulates the expression of nuclear hormone receptor co-repressors.BMC cell biology · 2006Article
- Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression.Molecular and cellular biology · 2005Article
- Towards understanding the epigenetics of transcription by chromatin structure and the nuclear matrix.Gene therapy & molecular biology · 2005Article
- The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription.Nucleic acids research · 2005Article
- The biology of human lymphoid malignancies revealed by gene expression profiling.Advances in immunology · 2005Review
- SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways.The Journal of biological chemistry · 2004Article
- Direct interaction of NRSF with TBP: chromatin reorganization and core promoter repression for neuron-specific gene transcription.Nucleic acids research · 2004Article
- The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien.Nucleic acids research · 2004Article
- Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression.Molecular and cellular biology · 2003Article
- Inhibition of polyomavirus ori-dependent DNA replication by mSin3B.Journal of virology · 2002Article
- Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor.Molecular and cellular biology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A variety of eukaryotic transcription factors, including the nuclear hormone receptors, Max-Mad, BCL-6, and PLZF, appear to mediate transcriptional repression through the ability to recruit a multiprotein corepressor complex to the target promoter. This corepressor complex includes the SMRT/N-CoR polypeptides, mSin3A or -B, and histone deacetylase 1 or 2. The presence of a histone-modifying activity in the corepressor complex has led to the suggestion that gene silencing is mediated by modification of the chromatin template, perhaps rendering it less accessible to the transcriptional machinery. We report here, however, that the corepressor complex actually appears to exhibit multiple mechanisms of transcriptional repression, only one of which corresponds with detectable recruitment of the histone deacetylase. We provide evidence instead of an alternative pathway of repression that may be mediated by direct physical interactions between components of the corepressor complex and the general transcription factor TFIIB.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.