ArticleMolecular and cellular biology1998
Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 83 citations in OpenAlex.
- Article
- DNA Replication and Sister Chromatid Cohesion 1 (DSCC1) of the Replication Factor Complex CTF18-RFC is Critical for Colon Cancer Cell Growth.Journal of Cancer · 2019Article
- Structural studies of RFCEMBO reports · 2017Article
- MTE1 Functions with MPH1 in Double-Strand Break Repair.Genetics · 2016Article
- Assembly of Slx4 signaling complexes behind DNA replication forks.The EMBO journal · 2015Article
- Rfc5p regulates alternate RFC complex functions in sister chromatid pairing reactions in budding yeast.Cell cycle (Georgetown, Tex.) · 2010Article
- The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress.Molecular and cellular biology · 2009Article
- Loading clamps for DNA replication and repair.DNA repair · 2009Review
- Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications.DNA repair · 2008Article
- Article
- Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast.Nucleic acids research · 2005Article
- Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA.PLoS biology · 2003Article
- XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus.Molecular biology of the cell · 2003Article
- Elg1 forms an alternative RFC complex important for DNA replication and genome integrity.The EMBO journal · 2003Article
- Mechanical link between cohesion establishment and DNA replication: Ctf7p/Eco1p, a cohesion establishment factor, associates with three different replication factor C complexes.Molecular and cellular biology · 2003Article
- Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Short telomeres induce a DNA damage response in Saccharomyces cerevisiae.Molecular biology of the cell · 2003Article
- Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block.Oncogene · 2002Article
- DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts.The Journal of cell biology · 2002Article
- Preferential binding of ATR protein to UV-damaged DNA.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RFC5 gene encodes a small subunit of replication factor C (RFC) complex in Saccharomyces cerevisiae and has been shown to be required for the checkpoints which respond to replication block and DNA damage. Here we describe the isolation of RAD24, known to play a role in the DNA damage checkpoint, as a dosage-dependent suppressor of rfc5-1. RAD24 overexpression suppresses the sensitivity of rfc5-1 cells to DNA-damaging agents and the defect in DNA damage-induced Rad53 phosphorylation. Rad24, like Rfc5, is required for the regulation of Rad53 phosphorylation in response to DNA damage. The Rad24 protein, which is structurally related to the RFC subunits, interacts physically with RFC subunits Rfc2 and Rfc5 and cosediments with Rfc5. Although the rad24Delta mutation alone does not cause a defect in the replication block checkpoint, it does enhance the defect in rfc5-1 mutants. Furthermore, overexpression of RAD24 suppresses the rfc5-1 defect in the replication block checkpoint. Taken together, our results demonstrate a physical and functional interaction between Rad24 and Rfc5 in the checkpoint pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.