ArticleThe Journal of clinical investigation1998
Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 109 citations in OpenAlex.
- Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions.The Journal of clinical investigation · 2003Trial
- B cell tolerance and autoimmunity: Lessons from repertoires.The Journal of experimental medicine · 2024Review
- Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans.Frontiers in immunology · 2022Review
- Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies.Immunological reviews · 2019Review
- Antibody repertoire analysis in polygenic autoimmune diseases.Immunology · 2018Review
- Evidence of Alternative Modes of B Cell Activation Involving Acquired Fab Regions of N-Glycosylation in Antibody-Secreting Cells Infiltrating the Labial Salivary Glands of Patients With Sjögren's Syndrome.Arthritis & rheumatology (Hoboken, N.J.) · 2018Article
- [Therapy-resistant cells of the B cell line].Zeitschrift fur Rheumatologie · 2016Review
- Transitional B Cells in Early Human B Cell Development - Time to Revisit the Paradigm?Frontiers in immunology · 2016Article
- IGK with conserved IGΚV/IGΚJ repertoire is expressed in acute myeloid leukemia and promotes leukemic cell migration.Oncotarget · 2015Article
- Secondary receptor editing in the generation of autoimmunity.Autoimmunity reviews · 2012Review
- B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients.Molecular immunology · 2012Article
- Immunoglobulin analysis tool: a novel tool for the analysis of human and mouse heavy and light chain transcripts.Frontiers in immunology · 2012Article
- The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases.Annals of the New York Academy of Sciences · 2011Review
- Mechanisms of B cell autoimmunity in SLE.Arthritis research & therapy · 2011Review
- B cell receptor editing in tolerance and autoimmunity.Annals of the New York Academy of Sciences · 2011Review
- [From stem cells to lymphocytes].Zeitschrift fur Rheumatologie · 2009Review
- Article
- Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning.Journal of immunological methods · 2008Article
- Reduced receptor editing in lupus-prone MRL/lpr mice.The Journal of experimental medicine · 2007Article
- Interleukin-6 is responsible for aberrant B-cell receptor-mediated regulation of RAG expression in systemic lupus erythematosus.Immunology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To determine whether receptor editing of Vkappa genes was involved in the pathogenesis of systemic lupus erythematosus (SLE), the usage of Vkappa and Jkappa gene elements from individual peripheral CD19(+) B cells obtained from a patient with untreated SLE was examined. No differences in the Vkappa and Jkappa gene usage in the nonproductive gene repertoire of this SLE patient were noted compared with the distribution of genes found in normal adults. However, an increased usage of Jkappa5 segments, and a significant overrepresentation of the Vkappa1 and Vkappa4 families, especially the L15, O14/O4, and B3 genes characterized the productive Vkappa gene repertoire of the SLE patient. Furthermore, Jkappa5-containing Vkappa gene rearrangements in the productive but not the nonproductive repertoire manifested significantly fewer mutations compared with Vkappa genes recombined with Jkappa1-4. These data are consistent with the conclusion that receptor editing of Vkappa is much more apparent in this SLE patient than in normals and suggest that a deficiency in this means to counteract the emergence of autoimmunity is not an essential feature of SLE.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.