ArticleThe American journal of pathology1998
Histochemical and ultrastructural modification of mucosal mast cell granules in parasitized mice lacking the beta-chymase, mouse mast cell protease-1.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 75 citations in OpenAlex.
- Neutrophil-activating protein inFrontiers in immunology · 2024Article
- Blocking the inhibitory receptor programmed cell death 1 prevents allergic immune response and anaphylaxis in mice.The Journal of allergy and clinical immunology · 2022Article
- Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation.The Journal of experimental medicine · 2021Article
- Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors.Journal of innate immunity · 2020Review
- Assessing the Sensitizing and Allergenic Potential of the Albumin and Globulin Fractions from Amaranth (Medicina (Kaunas, Lithuania) · 2019Article
- The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.The Journal of allergy and clinical immunology · 2018Article
- Interleukin-18 has an Important Role in Differentiation and Maturation of Mucosal Mast Cells.Journal of mucosal immunology research · 2018Article
- Role of interleukin-18 in the pathophysiology of allergic diseases.Cytokine & growth factor reviews · 2016Review
- IgE and mast cells in host defense against parasites and venoms.Seminars in immunopathology · 2016Review
- Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress.Biology of sex differences · 2016Article
- Approaches for analyzing the roles of mast cells and their proteases in vivo.Advances in immunology · 2015Review
- Mast cell secretory granules: armed for battle.Nature reviews. Immunology · 2014Review
- Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model.PloS one · 2014Article
- New models for analyzing mast cell functions in vivo.Trends in immunology · 2012Review
- Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice.Laboratory investigation; a journal of technical methods and pathology · 2012Article
- Alcian Blue and Pyronine Y histochemical stains permit assessment of multiple parameters in pulmonary disease models.Veterinary pathology · 2009Article
- Immunomodulatory mast cells: negative, as well as positive, regulators of immunity.Nature reviews. Immunology · 2008Review
- Aberrant mucosal mast cell protease expression in the enteric epithelium of nematode-infected mice lacking the integrin alphavbeta6, a transforming growth factor-beta1 activator.The American journal of pathology · 2007Article
- Expression profiling reveals novel innate and inflammatory responses in the jejunal epithelial compartment during infection with Trichinella spiralis.Infection and immunity · 2004Article
- Involvement of chymase-mediated angiotensin II generation in blood pressure regulation.The Journal of clinical investigation · 2004Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The soluble beta-chymases mouse mast cell protease-1 (mMCP-1) and rat mast cell protease-II are predominantly expressed by intestinal mucosal mast cells (IMMCs) and may promote mucosal epithelial permeability when released during intestinal allergic hypersensitivity responses. To study the function of these chymases, we generated mice with a homozygous null mutation of the mMCP-1 gene and investigated their response to infection with the intestinal nematode Nippostrongylus brasiliensis. Whereas mMCP-2, -4, and -5 were transcribed normally, there was no transcription of the mMCP-1 gene in null (-/-) mice, nor was mature mMCP-1 protein detected in (-/-) jejunal mucosa. In contrast, levels of mMCP-1 in wild-type (+/+) jejunal mucosa increased 200- to 350-fold from 0.66 microg mMCP-1/g wet weight in uninfected mice to 129 and 229 microg/g wet weight on days 8 and 10 of infection, respectively. The kinetics of IMMC recruitment differed in -/- mice compared with +/+ controls on days 8 (P < 0.05) and 10 (P < 0.03) of infection. The IMMCs in infected -/- mice stained poorly, if at all, for esterase with naphthol AS-D chloroacetate compared with the intense staining observed in +/+ controls. Ultrastructurally, the prominent crystal intragranular structures that are found in intraepithelial +/+ IMMCs were absent from -/- IMMCs. These data show that disruption of the mMCP-1 gene leads to profound histochemical and ultrastructural changes in IMMC granules.
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