ArticleProceedings of the National Academy of Sciences of the United States of America1998
Distribution of genes in the genome of Arabidopsis thaliana and its implications for the genome organization of plants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 74 citations in OpenAlex.
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- Patterns and evolution of nucleotide landscapes in seed plants.The Plant cell · 2012Article
- Insights from the GC content analysis of 76genome survey sequences (GSS) from Elaeisoleifera.Bioinformation · 2010Article
- Comparative genomics reveals conservative evolution of the xylem transcriptome in vascular plants.BMC evolutionary biology · 2010Article
- TILLING in the two-rowed barley cultivar 'Barke' reveals preferred sites of functional diversity in the gene HvHox1.BMC research notes · 2009Article
- The GC-heterogeneity of teleost fishes.BMC genomics · 2008Article
- Phylogenetic distribution of large-scale genome patchiness.BMC evolutionary biology · 2008Article
- Whole-genome analysis of Oryza sativa reveals similar architecture of two-component signaling machinery with Arabidopsis.Plant physiology · 2006Article
- Isochore structures in the genome of the plant Arabidopsis thaliana.Journal of molecular evolution · 2004Article
- The distribution of transgene insertion sites in barley determined by physical and genetic mapping.Genetics · 2004Article
- Gene content and density in banana ( Musa acuminata) as revealed by genomic sequencing of BAC clones.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2004Article
- National Science Foundation-sponsored workshop report. Draft plan for soybean genomics.Plant physiology · 2004Article
- Wavelet Analysis of DNA Bending Profiles reveals Structural Constraints on the Evolution of Genomic Sequences.Journal of biological physics · 2004Article
- Targeted analysis of orthologous phytochrome A regions of the sorghum, maize, and rice genomes using comparative gene-island sequencing.Plant physiology · 2002Article
- Genome properties of the diatom Phaeodactylum tricornutum.Plant physiology · 2002Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Previous work has shown that, in the large genomes of three Gramineae [rice, maize, and barley: 415, 2,500, and 5,300 megabases (Mb), respectively] most genes are clustered in long DNA segments (collectively called the "gene space") that represent a small fraction (12-24%) of nuclear DNA, cover a very narrow (0.8-1.6%) GC range, and are separated by vast expanses of gene-empty sequences. In the present work, we have analyzed the small (ca. 120 Mb) nuclear genome of Arabidopsis thaliana and shown that its organization is drastically different from that of the genomes of Gramineae. Indeed, (i) genes are distributed over about 85% of the main band of DNA in CsCl and cover an 8% GC range; (ii) ORFs are fairly evenly distributed in long (>50 kb) sequences from GenBank that amount to about 10 Mb; and (iii) the GC levels of protein-coding sequences (and of their third codon positions) are correlated with the GC levels of their flanking sequences. The different pattern of gene distribution of Arabidopsis compared with Gramineae appears to be because the genomes of the latter comprise (i) many large gene-empty regions separating gene clusters and (ii) abundant transposons in the intergenic sequences of gene clusters. Both sequences are absent or very scarce in the Arabidopsis genome. These observations provide a comparative view of angiosperm genome organization.
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