ArticleProceedings of the National Academy of Sciences of the United States of America1998
Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 330 papers, 8 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
330 citing papers in PubMed, 8 syntheses or guidelines pooled it, 854 citations in OpenAlex.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- Pooled it
- Association of Val158Met polymorphism in COMT gene with attention-deficit hyperactive disorder: An updated meta-analysis.Medicine · 2020Pooled it
- Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis.Metabolic brain disease · 2020Pooled it
- Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis.Psychiatric genetics · 2014Pooled it
- Role of COMT in ADHD: a systematic meta-analysis.Molecular neurobiology · 2014Pooled it
- The COMT Met158 allele and violence in schizophrenia: a meta-analysis.Schizophrenia research · 2012Pooled it
- A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia.PloS one · 2012Pooled it
- Catechol-O-methyltransferase activity does not influence emotional processing in men.Journal of psychopharmacology (Oxford, England) · 2022Trial
- Augmenting Frontal Dopamine Tone Enhances Maintenance over Gating Processes in Working Memory.Journal of cognitive neuroscience · 2021Trial
- Working memory, cortical dopamine tone, and frontoparietal brain recruitment in post-traumatic stress disorder: a randomized controlled trial.Translational psychiatry · 2021Trial
- Tolcapone Treatment for Cognitive and Behavioral Symptoms in Behavioral Variant Frontotemporal Dementia: A Placebo-Controlled Crossover Study.Journal of Alzheimer's disease : JAD · 2020Trial
- Effects of COMT genotype and tolcapone on lapses of sustained attention after sleep deprivation in healthy young men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Right inferior frontal cortex activity correlates with tolcapone responsivity in problem and pathological gamblers.NeuroImage. Clinical · 2017Trial
- Age moderates the effect of acute dopamine depletion on passive avoidance learning.Pharmacology, biochemistry, and behavior · 2015Trial
- Dopamine, locus of control, and the exploration-exploitation tradeoff.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Effects of acute dopamine precusor depletion on immediate reward selection bias and working memory depend on catechol-O-methyltransferase genotype.Journal of cognitive neuroscience · 2013Trial
- Dopamine, corticostriatal connectivity, and intertemporal choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Trial
- How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis.The European journal of neuroscience · 2012Trial
- Catecholamine metabolism revisited: from neurochemistry to integrative physiology and pathophysiology.Physiological reviews · 2026Review
270 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines and is considered a candidate for several psychiatric disorders and symptoms, including the psychopathology associated with the 22q11 microdeletion syndrome. By means of homologous recombination in embryonic stem cells, a strain of mice in which the gene encoding the COMT enzyme has been disrupted was produced. The basal concentrations of brain catecholamines were measured in the striatum, frontal cortex, and hypothalamus of adult male and female mutants. Locomotor activity, anxiety-like behaviors, sensorimotor gating, and aggressive behavior also were analyzed. Mutant mice demonstrated sexually dimorphic and region-specific changes of dopamine levels, notably in the frontal cortex. In addition, homozygous COMT-deficient female (but not male) mice displayed impairment in emotional reactivity in the dark/light exploratory model of anxiety. Furthermore, heterozygous COMT-deficient male mice exhibited increased aggressive behavior. Our results provide conclusive evidence for an important sex- and region-specific contribution of COMT in the maintenance of steady-state levels of catecholamines in the brain and suggest a role for COMT in some aspects of emotional and social behavior in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.