ArticleProceedings of the National Academy of Sciences of the United States of America1998
Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 97 citations in OpenAlex.
- Genome-Wide Study of the UK Biobank Highlights the Importance of the Homeobox-C Gene Cluster in Hip Fracture Risk.Geriatric orthopaedic surgery & rehabilitation · 2025Article
- Identification of a Chondrocyte-Specific Enhancer in theJournal of developmental biology · 2024Article
- Association ofGenes · 2022Article
- HOX genes in stem cells: Maintaining cellular identity and regulation of differentiation.Frontiers in cell and developmental biology · 2022Review
- DLX5 and HOXC8 enhance the chondrogenic differentiation potential of stem cells from apical papilla via LINC01013.Stem cell research & therapy · 2020Article
- Site-Dependent Lineage Preference of Adipose Stem Cells.Frontiers in cell and developmental biology · 2020Article
- Article
- Cross-Species RNA-Seq Study Comparing Transcriptomes of Enriched Osteocyte Populations in the Tibia and Skull.Frontiers in endocrinology · 2020Article
- miR-152 inhibits the proliferation and invasion of chordoma cells by targetingThe Journal of international medical research · 2019Article
- HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system.The International journal of developmental biology · 2018Article
- The predictive potential and oncogenic effects of HOXC8 expression on osteosarcoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Genes Frequently Coexpressed with Hoxc8 Provide Insight into the Discovery of Target Genes.Molecules and cells · 2016Article
- Developmental Patterning as a Quantitative Trait: Genetic Modulation of the Hoxb6 Mutant Skeletal Phenotype.PloS one · 2016Article
- Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte.Cell reports · 2015Article
- Role of Hox genes in stem cell differentiation.World journal of stem cells · 2015Review
- Molecular study of a Hoxa2 gain-of-function in chondrogenesis: a model of idiopathic proportionate short stature.International journal of molecular sciences · 2013Article
- Transgenic studies on homeobox genes in nervous system development: spina bifida in Isl1 transgenic mice.Transgenic research · 2013Article
- Article
- Unveiling novel genes upregulated by both rhBMP2 and rhBMP7 during early osteoblastic transdifferentiation of C2C12 cells.BMC research notes · 2011Article
- Expression of HOXC8 is inversely related to the progression and metastasis of pancreatic ductal adenocarcinoma.British journal of cancer · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Homeobox genes of the Hox class are required for proper patterning of skeletal elements, but how they regulate the differentiation of specific tissues is unclear. We show here that overexpression of a Hoxc-8 transgene causes cartilage defects whose severity depends on transgene dosage. The abnormal cartilage is characterized by an accumulation of proliferating chondrocytes and reduced maturation. Since Hoxc-8 is normally expressed in chondrocytes, these results suggest that Hoxc-8 continues to regulate skeletal development well beyond pattern formation in a tissue-specific manner, presumably by controlling the progression of cells along the chondrocyte differentiation pathway. The comparison to Hoxd-4 and Isl-1 indicates that this role in chondrogenesis is specific to proteins of the Hox class. Their capacity for regulation of cartilage differentiation suggests that Hox genes could also be involved in human chondrodysplasias or other cartilage disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.