ArticleProceedings of the National Academy of Sciences of the United States of America1998
Promoter-proximal stalling results from the inability to recruit transcription factor IIH to the transcription complex and is a regulated event.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- New Insights into HIV Life Cycle, Th1/Th2 Shift during HIV Infection and Preferential Virus Infection of Th2 Cells: Implications of Early HIV Treatment Initiation and Care.Life (Basel, Switzerland) · 2024Review
- Nucleotide excision repair: a versatile and smart toolkit.Acta biochimica et biophysica Sinica · 2022Review
- Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System.Vaccines · 2021Review
- AP-1 and NF-κB synergize to transcriptionally activate latent HIV upon T-cell receptor activation.FEBS letters · 2021Article
- Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome.Viruses · 2020Review
- Structure and mechanism of the RNA polymerase II transcription machinery.Genes & development · 2020Review
- TFIIB is only ∼9 Å away from the 5'-end of a trimeric RNA primer in a functional RNA polymerase II preinitiation complex.PloS one · 2015Article
- Article
- Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.Genes & development · 2009Article
- The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription.Genes & development · 2008Article
- An 8 nt RNA triggers a rate-limiting shift of RNA polymerase II complexes into elongation.The EMBO journal · 2006Article
- TFIIA plays a role in the response to oxidative stress.Eukaryotic cell · 2006Article
- TFIIH operates through an expanded proximal promoter to fine-tune c-myc expression.Molecular and cellular biology · 2005Article
- Transcriptional coactivator PC4 stimulates promoter escape and facilitates transcriptional synergy by GAL4-VP16.Molecular and cellular biology · 2004Article
- The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II.Molecular and cellular biology · 2003Article
- The regulatory role for the ERCC3 helicase of general transcription factor TFIIH during promoter escape in transcriptional activation.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences.Molecular and cellular biology · 2002Article
- Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo.The EMBO journal · 2001Article
- Promoter clearance by RNA polymerase II is an extended, multistep process strongly affected by sequence.Molecular and cellular biology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Promoter-proximal stalling, a general phenomenon observed during the expression of many RNA polymerase II transcribed genes, is dependent on transcription factor IIH (TFIIH). Reactions lacking TFIIH initiated transcription, but the transcription complex encountered a block to elongation proximal to the promoter. The accumulation of promoter-proximal stalled complexes was reduced in the presence of TFIIH and efficient escape from this site also required an activator. Promoter-proximal stalled complexes could not be induced to resume elongation. Our results indicate that effective recruitment of TFIIH into transcription complexes is achieved during formation of the preinitiation complex at the promoter. The studies establish that promoter clearance is a regulated event that requires TFIIH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.