ArticleThe EMBO journal1998
Receptor-oriented intercellular calcium waves evoked by vasopressin in rat hepatocytes.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 83 citations in OpenAlex.
- Inositol 1,4,5-trisphosphate receptor type 3 plays a protective role in hepatocytes during hepatic ischemia-reperfusion injury.Cell calcium · 2020Article
- Vasopressin Increases Urinary AcidificationJournal of the American Society of Nephrology : JASN · 2019Article
- Computational Modeling of Spatiotemporal Ca(2+) Signal Propagation Along Hepatocyte Cords.IEEE transactions on bio-medical engineering · 2016Article
- The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Differential Regulation of Multiple Steps in Inositol 1,4,5-Trisphosphate Signaling by Protein Kinase C Shapes Hormone-stimulated Ca2+ Oscillations.The Journal of biological chemistry · 2015Article
- Calcium signaling in the liver.Comprehensive Physiology · 2013Review
- Calcium signalling and liver regeneration.International journal of hepatology · 2012Article
- Heterogeneous expression of suppressor of cytokine signalling 2 (SOCS-2) in liver tissue.Journal of anatomy · 2009Article
- The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves.The Journal of biological chemistry · 2007Article
- Is there a specific role for the plasma membrane Ca2+ -ATPase in the hepatocyte?Molecular and cellular biochemistry · 2006Review
- Intercellular calcium signalling in cultured renal epithelia: a theoretical study of synchronization mode and pacemaker activity.European biophysics journal : EBJ · 2004Article
- Intercellular Ca2+ wave propagation through gap-junctional Ca2+ diffusion: a theoretical study.Biophysical journal · 2001Article
- Model of intercellular calcium oscillations in hepatocytes: synchronization of heterogeneous cells.Biophysical journal · 1999Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Agonist-induced intracellular calcium signals may propagate as intercellular Ca2+ waves in multicellular systems as well as in intact organs. The mechanisms initiating intercellular Ca2+ waves in one cell and determining their direction are unknown. We investigated these mechanisms directly on fura2-loaded multicellular systems of rat hepatocytes and on cell populations issued from peripheral (periportal) and central (perivenous) parts of the hepatic lobule. There was a gradient in vasopressin sensitivity along connected cells as demonstrated by low vasopressin concentration challenge. Interestingly, the intercellular sensitivity gradient was abolished either when D-myo-inositol 1,4, 5-trisphosphate (InsP3) receptor was directly stimulated after flash photolysis of caged InsP3 or when G proteins were directly stimulated with AlF4-. The gradient in vasopressin sensitivity in multiplets was correlated with a heterogeneity of vasopressin sensitivity in the hepatic lobule. There were more vasopressin-binding sites, vasopressin-induced InsP3 production and V1a vasopressin receptor mRNAs in perivenous than in periportal cells. Therefore, we propose that hormone receptor density determines the cellular sensitivity gradient from the peripheral to the central zones of the liver cell plate, thus the starting cell and the direction of intercellular Ca2+ waves, leading to directional activation of Ca2+-dependent processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.