ArticleThe EMBO journal1998
syk protein tyrosine kinase regulates Fc receptor gamma-chain-mediated transport to lysosomes.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- Src- and Abl-family kinases activate spleen tyrosine kinase to maximize phagocytosis and Leishmania infection.Journal of cell science · 2023Article
- The transmembrane adapter SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs.The Journal of biological chemistry · 2022Article
- Leveraging Antibody, B Cell and Fc Receptor Interactions to Understand Heterogeneous Immune Responses in Tuberculosis.Frontiers in immunology · 2022Review
- Cancer-Cell-Derived IgG and Its Potential Role in Tumor Development.International journal of molecular sciences · 2021Review
- FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity.The Journal of experimental medicine · 2020Article
- The role of IgG Fc receptors in antibody-dependent enhancement.Nature reviews. Immunology · 2020Review
- Article
- Review
- Diversification of IgG effector functions.International immunology · 2017Review
- FcγRIIIa Signaling Modulates Endosomal TLR Responses in Human CD4Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Signaling by Antibodies: Recent Progress.Annual review of immunology · 2017Review
- Anti-retroviral antibody FcγR-mediated effector functions.Immunological reviews · 2017Review
- The Role and Function of Fcγ Receptors on Myeloid Cells.Microbiology spectrum · 2016Review
- Immunoregulatory functions of immune complexes in vaccine and therapy.EMBO molecular medicine · 2016Review
- Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Scavenger receptor function of mouse Fcγ receptor III contributes to progression of atherosclerosis in apolipoprotein E hyperlipidemic mice.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The function of Fcγ receptors in dendritic cells and macrophages.Nature reviews. Immunology · 2014Review
- Therapeutic targeting of Syk in autoimmune diabetes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Oxidative stress decreases phosphatidylinositol 4,5-bisphosphate levels by deactivating phosphatidylinositol- 4-phosphate 5-kinase beta in a Syk-dependent manner.The Journal of biological chemistry · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B- and T-cell receptors, as well as most Fc receptors (FcR), are part of a large family of membrane proteins named immunoreceptors and are expressed on all cells of the immune system. Immunoreceptors' biological functions rely on two of their fundamental attributes: signal transduction and internalization. The signals required for these two functions are present in the chains associated with immunoreceptors, within conserved amino acid motifs called immunoreceptor tyrosine-based activation motifs (ITAMs). We have examined the role of the protein tyrosine kinase (PTK) syk, a critical effector of immunoreceptor-mediated cell signalling through ITAMs, in FcR-associated gamma-chain internalization and lysosomal targeting. A point mutation in the immunoreceptor-associated gamma-chain ITAM affecting syk activation, as well as overexpression of a syk dominant negative mutant, inhibited signal transduction without affecting receptor coated-pit localization or internalization. In contrast, blocking of gamma-chain-mediated syk activation impaired FcR transport from endosomes to lysosomes and selectively inhibited the presentation of certain T-cell epitopes. Therefore, activation of the PTK syk is dispensable for receptor internalization, but necessary for cell signalling and for gamma-chain-mediated FcR delivery to lysosomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.