ReviewInvertebrate neuroscience : IN1997
Nitric oxide signaling in invertebrates.
Review in Invertebrate neuroscience : IN, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 132 citations in OpenAlex.
- Comparative study of the role of nitric oxide in the regulation of food intake across vertebrates.Journal of veterinary science · 2026Review
- Prioritising research on endocrine disruption in the marine environment: a global perspective.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Review
- Role of the Neuroendocrine System of Marine Bivalves in Their Response to Hypoxia.International journal of molecular sciences · 2023Review
- Effect of Air Exposure-Induced Hypoxia on Neurotransmitters and Neurotransmission Enzymes in Ganglia of the ScallopInternational journal of molecular sciences · 2022Article
- The chemical brain hypothesis for the origin of nervous systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Insect Behavioral Change and the Potential Contributions of Neuroinflammation-A Call for Future Research.Genes · 2021Review
- Nitric oxide mediates metabolic functions in the bivalve Arctica islandica under hypoxia.PloS one · 2020Article
- Role of nitric oxide in the induction of the behavioral and cellular changes produced by a common aversive stimulus in Aplysia.Behavioural brain research · 2019Article
- cGMP mediates short- and long-term modulation of excitability in a decision-making neuron in Aplysia.Neuroscience letters · 2018Article
- Hypoxically Induced Nitric Oxide: Potential Role as a Vasodilator inFrontiers in physiology · 2018Article
- An ancient role for nitric oxide in regulating the animal pelagobenthic life cycle: evidence from a marine sponge.Scientific reports · 2016Article
- Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans.SAGE open medicine · 2015Article
- A kinetic approach to assess oxidative metabolism related features in the bivalve Mya arenaria.Theory in biosciences = Theorie in den Biowissenschaften · 2012Article
- Control of luminescence from lantern shark (Etmopterus spinax) photophores.Communicative & integrative biology · 2011Article
- Nitric oxide: perspectives and emerging studies of a well known cytotoxin.International journal of molecular sciences · 2010Review
- Neuroactive substances specifically modulate rhythmic body contractions in the nerveless metazoon Tethya wilhelma (Demospongiae, Porifera).Frontiers in zoology · 2006Article
- Nitric oxide is necessary for multiple memory processes after learning that a food is inedible in aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Critical time-window for NO-cGMP-dependent long-term memory formation after one-trial appetitive conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Neural network partitioning by NO and cGMP.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is an unconventional neurotransmitter and neuromodulator molecule that is increasingly found to have important signaling functions in animals from nematodes to mammals. NO signaling mechanisms in the past were identified largely through experiments on mammals, after the discovery of NO's vasodilatory functions. The use of gene knock out mice has been particularly important in revealing the functions of the several isoforms of nitric oxide synthase (NOS), the enzyme that produces NO. Recent studies have revealed rich diversity in NO signaling. In addition to the well-established pathway in which NO activates guanylyl cyclase and cGMP production, redox mechanisms involving protein nitrosylation are important contributors to modulation of neurotransmitter release and reception. NO signaling studies in invertebrates are now generating a wealth of comparative information. Invertebrate NOS isoforms have been identified in insects and molluscs, and the conserved and variable amino acid sequences evaluated. Calcium-calmodulin dependence and cofactor requirements are conserved. NADPH diaphorase studies show that NOS is found in echinoderms, coelenterates, nematodes, annelids, insects, crustaceans and molluscs. Accumulating evidence reveals that NO is used as an orthograde transmitter and cotransmitter, and as a modulator of conventional transmitter release. NO appears to be used in diverse animals for certain neuronal functions, such as chemosensory signaling, learning, and development, suggesting that these NO functions have been conserved during evolution. The discovery of NO's diverse and unconventional signaling functions has stimulated a plethora of enthusiastic investigations into its uses. We can anticipate the discovery of many more interesting and some surprising NO signaling functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.