ArticleThe Journal of physiology1998
Age and gender differences in excitation-contraction coupling of the rat ventricle.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Effect of estrogen and testosterone on cardiac electrophysiology and atrial fibrillation.Heart rhythm O2 · 2026Review
- Sex differences in ventricular muscle energetics in a type 2 diabetic rat model.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Sex differences in cardiac energetics in the rat ventricular muscle.Scientific reports · 2024Article
- Connecting transcriptomics with computational modeling to reveal developmental adaptations in pediatric human atrial tissue.American journal of physiology. Heart and circulatory physiology · 2024Article
- Isolated cardiac muscle contracting against a real-time model of systemic and pulmonary cardiovascular loads.American journal of physiology. Heart and circulatory physiology · 2023Article
- The effect of sex and age on ex vivo cardiac electrophysiology: insight from a guinea pig model.American journal of physiology. Heart and circulatory physiology · 2023Article
- Sex differences in heart: from basics to clinics.European journal of medical research · 2022Review
- Higher NaInternational journal of molecular sciences · 2022Article
- Reevaluating methods reporting practices to improve reproducibility: an analysis of methodological rigor for the Langendorff whole heart technique.American journal of physiology. Heart and circulatory physiology · 2022Review
- General anesthesia and electrocardiographic parameters in in vivo experiments involving rats.Physiological research · 2022Article
- Estrogen regulation of cardiac cAMP-L-type CaCell communication and signaling : CCS · 2019Article
- The Role of 17β-Estradiol and Estrogen Receptors in Regulation of CaFrontiers in endocrinology · 2019Review
- Age- and strain-related aberrant CaAmerican journal of physiology. Heart and circulatory physiology · 2017Article
- Arrhythmogenic effect of androgens on the rat heart.The journal of physiological sciences : JPS · 2017Article
- Characterization of the sex-dependent myocardial S-nitrosothiol proteome.American journal of physiology. Heart and circulatory physiology · 2016Article
- Effects of sleep deprivation on action potential and transient outward potassium current in ventricular myocytes in rats.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Does sex influence the incidence or severity of reperfusion-induced cardiac arrhythmias?SpringerPlus · 2015Article
- Sex differences in stretch-dependent effects on tension and Ca(2+) transient of rat trabeculae in monocrotaline pulmonary hypertension.The journal of physiological sciences : JPS · 2015Article
- Sex differences in the mechanisms underlying long QT syndrome.American journal of physiology. Heart and circulatory physiology · 2014Review
- Sex-based differences in cardiac ischaemic injury and protection: therapeutic implications.British journal of pharmacology · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The objective of this study was to determine potential post-pubertal gender-specific differences in the contractility of papillary muscles, the electrophysiological properties and Ca2+ transients of freshly dissociated ventricular myocytes from the rat heart. 2. The contractions of rat papillary muscles from 2- to 14-month-old male and female rats were studied under isometric and isotonic conditions (29 degrees C). While the hearts of young (2-4 months) male and female rats displayed a similar contractile profile, papillary muscles of female rats aged 6 months and older exhibited smaller isometric and isotonic contractions, smaller maximal rates of tension and shortening development and decline (+/-DT/dt and +/-DL/dt) velocities during both the onset and relaxation phases, and shorter contractions than age-matched males. 3. To explore the possible cellular basis accounting for these differences, action potentials and macroscopic currents were recorded from freshly dissociated myocytes using the whole-cell patch clamp technique (35 C). Action potentials from male and female myocytes of 3- and 9-month-old rats did not vary as a function of age or gender. Consistent with these results, the magnitude (expressed in pA pF-1), voltage-dependence and kinetics of the inward rectifier (IK1), transient outward (Ito) and sustained (IK) K+ currents displayed little, if any dependence on age or gender. 4. L-type Ca2+ current (ICa(L)) measured in caesium-loaded myocytes (35 C) from male and female rats of 3, 6 and 9 months of age exhibited similar characteristics. In contrast, while Ca2+ transients measured with indo-1 were similar between 3-month-old male and female rat myocytes, Ca2+ transients of 10-month-old female myocytes were significantly reduced and showed a diminished rate of relaxation in comparison with those recorded in male rats of similar age. 5. These results suggest that important gender-related changes in excitation-contraction coupling occur following puberty, probably due to differences in Ca2+ handling capabilities at the level of the sarcoplasmic reticulum.
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