ArticleThe Journal of physiology1998
Role of an inward rectifier K+ current and of hyperpolarization in human myoblast fusion.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 74 citations in OpenAlex.
- Hyperpolarization by Optogenetic Activation of NpHR Channels Promotes Osteogenic Differentiation of Human Dental Follicle Stem Cells.Membranes · 2026Article
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- A Pharmacological Investigation of the TMEM16A Currents in Murine Skeletal Myogenic Precursor Cells.International journal of molecular sciences · 2024Article
- Ion Channels and Transporters in Muscle Cell Differentiation.International journal of molecular sciences · 2021Review
- Weak Electromagnetic Fields Accelerate Fusion of Myoblasts.International journal of molecular sciences · 2021Article
- Bioelectrical domain walls in homogeneous tissues.Nature physics · 2020Article
- The LRRC8/VRAC anion channel facilitates myogenic differentiation of murine myoblasts by promoting membrane hyperpolarization.The Journal of biological chemistry · 2019Article
- Bioelectric Properties of Myogenic Progenitor Cells.Bioelectricity · 2019Review
- Membrane Potential Depolarization Alters Calcium Flux and Phosphate Signaling During Osteogenic Differentiation of Human Mesenchymal Stem Cells.Bioelectricity · 2019Article
- Bioelectric regulation of innate immune system function in regenerating and intactNPJ Regenerative medicine · 2017Article
- Sustained Depolarization of the Resting Membrane Potential Regulates Muscle Progenitor Cell Growth and Maintains Stem Cell Properties In Vitro.Stem cell reviews and reports · 2016Article
- Article
- Depolarization alters phenotype, maintains plasticity of predifferentiated mesenchymal stem cells.Tissue engineering. Part A · 2013Article
- Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer.Journal of clinical & experimental oncology · 2013Article
- Membrane potential and cancer progression.Frontiers in physiology · 2013Article
- Epidermal growth factor receptor down-regulation triggers human myoblast differentiation.PloS one · 2013Article
- Role of membrane potential in the regulation of cell proliferation and differentiation.Stem cell reviews and reports · 2009Review
- Potassium currents in human myogenic cells from healthy and congenital myotonic dystrophy foetuses.Cellular & molecular biology letters · 2009Article
- Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells.PloS one · 2008Article
- Extracellular guanosine-5'-triphosphate modulates myogenesis via intermediate Ca(2+)-activated K+ currents in C2C12 mouse cells.The Journal of physiology · 2006Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The role of K+ channels and membrane potential in myoblast fusion was evaluated by examining resting membrane potential and timing of expression of K+ currents at three stages of differentiation of human myogenic cells: undifferentiated myoblasts, fusion-competent myoblasts (FCMBs), and freshly formed myotubes. 2. Two K+ currents contribute to a hyperpolarization of myoblasts prior to fusion: IK(NI), a non-inactivating delayed rectifier, and IK(IR), an inward rectifier. 3. IK(NI) density is low in undifferentiated myoblasts, increases in FCMBs and declines in myotubes. On the other hand, IK(IR) is expressed in 28% of the FCMBs and in all myotubes. 4. IK(IR) is reversibly blocked by Ba2+ or Cs+. 5. Cells expressing IK(IR) have resting membrane potentials of -65 mV. A block by Ba2+ or Cs+ induces a depolarization to a voltage determined by IK(NI) (-32 mV). 6. Cs+ and Ba2+ ions reduce myoblast fusion. 7. It is hypothesized that the IK(IR)-mediated hyperpolarization allows FCMBs to recruit Na+, K+ and T-type Ca2+ channels which are present in these cells and would otherwise be inactivated. FCMBs, rendered thereby capable of firing action potentials, could amplify depolarizing signals and may accelerate fusion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.