ArticleThe Journal of physiology1998
Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneurones.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 71 citations in OpenAlex.
- Energy-dependent modulation of nucleus accumbens output via K-ATP channel activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Does Dysregulation Of The Indirect Pathway Contribute To The Pathophysiology Of Catatonia Through Neurotransmitter Imbalance?Clinical neuropsychiatry · 2025Article
- Cognitive effects of thalamostriatal degeneration are ameliorated by normalizing striatal cholinergic activity.Science advances · 2023Article
- Review
- The surprising complexity of KATP channel biology and of genetic diseases.The Journal of clinical investigation · 2020Article
- Cholinergic modulation of striatal microcircuits.The European journal of neuroscience · 2019Review
- Modulation of Excitability of Stellate Neurons in the Ventral Cochlear Nucleus of Mice by ATP-Sensitive Potassium Channels.The Journal of membrane biology · 2018Article
- Novel human ABCC9/SUR2 brain-expressed transcripts and an eQTL relevant to hippocampal sclerosis of aging.Journal of neurochemistry · 2015Article
- Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions.Annals of the New York Academy of Sciences · 2015Review
- Striatal cholinergic interneuron regulation and circuit effects.Frontiers in synaptic neuroscience · 2014Review
- Acetylcholine encodes long-lasting presynaptic plasticity at glutamatergic synapses in the dorsal striatum after repeated amphetamine exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Subsecond regulation of striatal dopamine release by pre-synaptic KATP channels.Journal of neurochemistry · 2011Article
- Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells.Respiratory physiology & neurobiology · 2011Article
- Glucose deprivation activates diversity of potassium channels in cultured rat hippocampal neurons.Cellular and molecular neurobiology · 2006Article
- Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- ATP-sensitive potassium channels induced in liver cells after transfection with insulin cDNA and the GLUT 2 transporter regulate glucose-stimulated insulin secretion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2003Article
- Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel.The Journal of physiology · 2003Article
- Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Intrinsic membrane properties underlying spontaneous tonic firing in neostriatal cholinergic interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Histamine depolarizes cholinergic interneurones in the rat striatum via a H(1)-receptor mediated action.British journal of pharmacology · 2000Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Whole-cell patch-clamp recordings were made from rat striatal cholinergic interneurones in slices of brain tissue in vitro. In the absence of ATP in the electrode solution, these neurones were found to gradually hyperpolarize through the induction of an outward current at -60 mV. This outward current and the resultant hyperpolarization were blocked by the sulphonylureas tolbutamide and glibenclamide and by the photorelease of caged ATP within neurones. 2. This ATP-sensitive outward current was not observed when 2 mM ATP was present in the electrode solution. Under these conditions, 500 microM diazoxide was found to induce an outward current that was blocked by tolbutamide. 3. Using permeabilized patch recordings, neurones were shown to hyperpolarize in response to glucose deprivation or metabolic poisoning with sodium azide (NaN3). The resultant hyperpolarization was blocked by tolbutamide. 4. In cell-attached recordings, metabolic inhibition with 1 mM NaN3 revealed the presence of a tolbutamide-sensitive channel exhibiting a unitary conductance of 44.1 pS. 5. Reverse transcription followed by the polymerase chain reaction using cytoplasm from single cholinergic interneurones demonstrated the expression of the ATP-sensitive potassium (KATP) channel subunits Kir6.1 and SUR1 but not Kir6.2 or SUR2. 6. It is concluded that cholinergic interneurones within the rat striatum exhibit a KATP channel current and that this channel is formed from Kir6.1 and SUR1 subunits.
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