ArticleThe Journal of experimental medicine1998
Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 133 citations in OpenAlex.
- BCR signal strength governs VH gene replacement in peripheral B cells.Cellular & molecular immunology · 2026Article
- Lineage Reconstruction of In Vitro Identified Antigen-Specific Autoreactive B Cells from Adaptive Immune Receptor Repertoires.International journal of molecular sciences · 2022Article
- Antigen nature and complexity influence human antibody light chain usage and specificity.Vaccine · 2016Article
- Article
- B-cell pathology in juvenile idiopathic arthritis.Arthritis · 2010Article
- Patterns of receptor revision in the immunoglobulin heavy chains of a teleost fish.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans.Immunity · 2008Article
- B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice.The Journal of clinical investigation · 2008Article
- Interleukin-6 is responsible for aberrant B-cell receptor-mediated regulation of RAG expression in systemic lupus erythematosus.Immunology · 2007Article
- Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion.The Journal of experimental medicine · 2007Article
- Differential expression patterns of recombination-activating genes in individual mature B cells in juvenile idiopathic arthritis.Annals of the rheumatic diseases · 2006Article
- Analysis of RAG expression by peripheral blood CD5+ and CD5- B cells of patients with childhood systemic lupus erythematosus.Annals of the rheumatic diseases · 2006Article
- Receptor editing in peripheral B cell tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Bruton's tyrosine kinase is essential for human B cell tolerance.The Journal of experimental medicine · 2004Article
- Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily.The Journal of experimental medicine · 2004Article
- Insights into the regulation of immunoglobulin light chain gene rearrangements via analysis of the kappa light chain locus in lambda myeloma.Immunology · 2004Article
- Recombination activating genes (RAG) induce secondary Ig gene rearrangement in and subsequent apoptosis of human peripheral blood circulating B lymphocytes.Clinical and experimental immunology · 2004Article
- Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.The Journal of experimental medicine · 2004Article
- Transcriptional analysis of the B cell germinal center reaction.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Transcript expression of two Iglambda rearrangements and RAG-1/RAG-2 in a mature human B cell producing IgMlambda islet cell autoantibody.Journal of clinical immunology · 2003Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 3 countries.
Funding
Abstract
The germinal center (GC) is an anatomic compartment found in peripheral lymphoid organs, wherein B cells undergo clonal expansion, somatic mutation, switch recombination, and reactivate immunoglobulin gene V(D)J recombination. As a result of somatic mutation, some GC B cells develop higher affinity antibodies, whereas others suffer mutations that decrease affinity, and still others may become self-reactive. It has been proposed that secondary V(D)J rearrangements in GCs might rescue B cells whose receptors are damaged by somatic mutations. Here we present evidence that mature human tonsil B cells coexpress conventional light chains and recombination associated genes, and that they extinguish recombination activating gene and terminal deoxynucleotidyl transferase expression when their receptors are cross-linked. Thus, the response of the recombinase to receptor engagement in peripheral B cells is the opposite of the response in developing B cells to the same stimulus. These observations suggest that receptor revision is a mechanism for receptor diversification that is turned off when antigen receptors are cross-linked by the cognate antigen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.