ArticleNucleic acids research1998
NGG-triplet repeats form similar intrastrand structures: implications for the triplet expansion diseases.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Predicting Single-Stranded DNA Oligonucleotides 3D Structures: An Open Issue.Computational and structural biotechnology journal · 2026Article
- The Influence of CG sites on dynamic DNA sequence mutagenesis in the genomic evolution of mammalian lifespan.Nucleic acids research · 2025Article
- NMR structure of a G-quadruplex formed by four d(G4C2) repeats: insights into structural polymorphism.Nucleic acids research · 2018Article
- Large Deletions at the SHOX Locus in the Pseudoautosomal Region Are Associated with Skeletal Atavism in Shetland Ponies.G3 (Bethesda, Md.) · 2016Article
- Mutsβ generates both expansions and contractions in a mouse model of the Fragile X-associated disorders.Human molecular genetics · 2015Article
- Heterozygosity for a hypomorphic Polβ mutation reduces the expansion frequency in a mouse model of the Fragile X-related disorders.PLoS genetics · 2015Article
- The transcription-coupled repair protein ERCC6/CSB also protects against repeat expansion in a mouse model of the fragile X premutation.Human mutation · 2015Article
- Stability Constants of Mixed Ligand Complexes of Nickel(II) with Adenine and Some Amino Acids.Bioinorganic chemistry and applications · 2015Article
- Repeat-associated non-AUG translation and its impact in neurodegenerative disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
- Human AP endonuclease inefficiently removes abasic sites within G4 structures compared to duplex DNA.Nucleic acids research · 2014Article
- Chromosome fragility and the abnormal replication of the FMR1 locus in fragile X syndrome.Human molecular genetics · 2014Article
- Repeat-mediated genetic and epigenetic changes at the FMR1 locus in the Fragile X-related disorders.Frontiers in genetics · 2014Review
- A Rare, Recurrent, De Novo 14q32.2q32.31 Microdeletion of 1.1 Mb in a 20-Year-Old Female Patient with a Maternal UPD(14)-Like Phenotype and Intellectual Disability.Case reports in genetics · 2014Article
- The biological effects of simple tandem repeats: lessons from the repeat expansion diseases.Genome research · 2008Review
- Replication fork stalling at natural impediments.Microbiology and molecular biology reviews : MMBR · 2007Review
- Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.Nucleic acids research · 2007Review
- Advances in mechanisms of genetic instability related to hereditary neurological diseases.Nucleic acids research · 2005Review
- DNA elements important for CAG*CTG repeat thresholds in Saccharomyces cerevisiae.Nucleic acids research · 2004Article
- The guanine-rich fragile X chromosome repeats are reluctant to form tetraplexes.Nucleic acids research · 2004Article
- The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer.Nucleic acids research · 2003Article
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Abstract
Tandem repeats of certain trinucleotides show extensive intergenerational instability in humans that is associated with a class of genetic disorders known as the Triplet Expansion Diseases. This instability is thought to be a consequence of the formation of intrastrand structures, including hairpins, triplexes and tetraplexes, by the tandem repeats. I show here that CGG-repeats which are associated with this group of diseases, and AGG- and TGG-repeats which are not currently known to be, form several intrastrand structures including tetraplexes. In all cases the tetraplexes have the same overall conformation in which all the G residues are involved in G4-tetrads. CGG-repeats also form stable hairpins, but AGG- and TGG-repeats do not form hairpins of comparable stability. However, since tetraplexes can be thought of as folded hairpins, many of the properties ascribed to disease-associated triplets that form hairpins, may apply to these sequences as well. The fact that AGG- and TGG-repeats are not currently associated with any triplet expansion disease suggests either that the ability to adopt an intrastrand folded structure is not sufficient for expansion, or that other diseases associated with such triplets might remain to be identified.
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