ArticleNucleic acids research1998
HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses.Protein & cell · 2011Article
- Mouse Rad1 deletion enhances susceptibility for skin tumor development.Molecular cancer · 2010Article
- Transcriptional profiling of the age-related response to genotoxic stress points to differential DNA damage response with age.Mechanisms of ageing and development · 2009Article
- Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha.Molecular cancer · 2008Article
- Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality.Molecular and cellular biology · 2004Article
- Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9.The EMBO journal · 2003Article
- c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.Molecular and cellular biology · 2002Article
- PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition.Oncogene · 2000Article
- Mutant alleles of Schizosaccharomyces pombe rad9(+) alter hydroxyurea resistance, radioresistance and checkpoint control.Nucleic acids research · 2000Article
- The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1.Molecular biology of the cell · 1999Article
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3 authors.
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Abstract
Eukaryotic cells arrest at the G2checkpoint in the presence of DNA damage or incompletely replicated DNA. This cell cycle checkpoint prevents the development and propagation of genomic instability. In the fission yeast, this process requires the action of a number of genes, including rad1(+) . We report here the identification of human and mouse cDNAs that exhibit extensive sequence homology to rad1(+) . The human gene, called HRAD1 , encodes a 282 amino acid protein that is 27% identical and 53% similar to yeast Rad1p. The human homologue maintains its sequence similarity over the full length of the protein, including the three proposed 3'-->5' exonuclease domains, and the leucine rich repeat region. The mouse gene, called MRAD1 , encodes a 280 amino acid protein that is 90% identical and 96% similar to HRAD1 at the amino acid level. Expression of HRAD1 in yeast rad1 mutants partially restores radiation resistance and G2checkpoint proficiency to these mutants. Evolutionaryconservation of structure between HRAD1 , MRAD1 , rad1(+), Saccharomyces cerevisiae RAD17 and the Ustilago maydis REC1 checkpoint genes suggests that the function of the encoded proteins is conserved as well. The ability of HRAD1 to partially complement yeast rad1 mutants suggests that this gene is required for G2checkpoint control in human cells.
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