ArticleBMJ (Clinical research ed.)1998
Why are patients prescribed proton pump inhibitors? Retrospective analysis of link between morbidity and prescribing in the General Practice Research Database.
Article in BMJ (Clinical research ed.), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Proton pump inhibitors for chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2020Pooled it
- An automated tool for detecting medication overuse based on the electronic health records.Pharmacoepidemiology and drug safety · 2013Trial
- Morbidity profile and pharmaceutical management of adult outpatients between primary and tertiary care levels in Sri Lanka: a dual-centre, comparative study.BMC primary care · 2024Article
- Patients' Knowledge and Pharmacists' Practice Regarding the Long-Term Side Effects of Proton Pump Inhibitors; a Cross-sectional Study.Archives of academic emergency medicine · 2024Article
- Anti-Proliferative Properties, Biocompatibility, and Chemical Composition of Different Extracts of Plantago major Medicinal Plant.Iranian biomedical journal · 2021Article
- Using a Triple Aim Approach to Implement "Less-is-More Together" and Smarter Medicine Strategies in an Interprofessional Outpatient Setting: Protocol for an Observational Study.JMIR research protocols · 2019Article
- The impact of proton pump inhibitors on the human gastrointestinal microbiome.Clinics in laboratory medicine · 2014Review
- Should peri-gastrectomy gastric acidity be our focus among gastric cancer patients?World journal of gastroenterology · 2014Article
- Analysis of medication and indication occurrences in clinical notes.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2014Article
- Use of proton pump inhibitors is associated with lower trabecular bone density in older individuals.Bone · 2013Article
- Proton pump inhibitors and risk for recurrent Clostridium difficile infection among inpatients.The American journal of gastroenterology · 2013Article
- Operationalising factors that explain the emergence of infectious diseases: a case study of the human campylobacteriosis epidemic.PloS one · 2013Article
- Chronic proton pump inihibitor therapy and calcium metabolism.Current gastroenterology reports · 2012Review
- Use of Proton Pump Inhibitor and Risk of Colorectal Cancer: A Meta-analysis of Observational Studies.Korean journal of family medicine · 2012Article
- Inappropriate prescribing of proton pump inhibitors in older patients: effects of an educational strategy.Drugs & aging · 2012Article
- Overutilization of proton-pump inhibitors: what the clinician needs to know.Therapeutic advances in gastroenterology · 2012Article
- Proton pump inhibitors: use, misuse and concerns about long-term therapy.Clinical journal of gastroenterology · 2011Article
- Use of proton pump inhibitors and H2 blockers and risk of pneumonia in older adults: a population-based case-control study.Pharmacoepidemiology and drug safety · 2010Article
- The role of protein digestibility and antacids on food allergy outcomes.The Journal of allergy and clinical immunology · 2008Review
- Hip fractures in users of first- vs. second-generation bisphosphonates.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo establish the relation between new prescriptions for proton pump inhibitors and recorded upper gastrointestinal morbidity within a large computerised general practitioner database.
designRetrospective survey of morbidity and prescribing data linked to new prescriptions for proton pump inhibitors and comparison with licensed indications between 1991 and 1995.
settingGeneral Practice Research Database and prescribing analysis and cost (PACT) data for the former West Midlands region. SUBJECTS: Information for 612 700 patients in the General Practice Research Database. Anonymous PACT data for all general practitioners in West Midlands region.
main outcome measuresDiagnostic codes linked to the first prescriptions issued for proton pump inhibitors; relation between new prescriptions and licensed indications; yearly change in ratio of new to repeat prescriptions and prescribing volumes measured as defined daily doses.
resultsOesophagitis was the commonest recorded indication in 1991, accounting for 31% of new prescriptions, but was third in 1995 (14%). During the study new prescriptions increased substantially, especially for duodenal disease (780%) and non-ulcer dyspepsia (690%). In 1995 non-specific morbidity accounted for 46% of new prescriptions. The total volume of prescribing rose 10-fold between 1991 and 1995, when repeat prescribing accounted for 77% of the total.
conclusionsChanges in recorded morbidity associated with new prescriptions of proton pump inhibitors did not necessarily reflect changes in licensed indications. Although general practitioners seemed to respond to changes in licensing, particularly for duodenal and gastric disease, prescribing for unlicensed indications non-ulcer dyspepsia and non-specific abdominal pain increased.
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