ArticleScience (New York, N.Y.)1998
RETRACTED: BRCA1 required for transcription-coupled repair of oxidative DNA damage.
Article in Science (New York, N.Y.), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 116 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed, 498 citations in OpenAlex.
- NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis.Nature metabolism · 2025Article
- Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology.Molecules (Basel, Switzerland) · 2022Article
- A clinical case of diagnosis of breast cancer in patients with family history ofReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2021Article
- Genetic polymorphisms and haplotypes of BRCA1 gene associated with quality of life and survival among patients with non-small-cell lung cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- ZebrafishGenes · 2020Article
- Dental-craniofacial manifestation and treatment of rare diseases.International journal of oral science · 2019Review
- Interferon-γ signaling is associated withNPJ precision oncology · 2019Article
- Expression of RING Finger Protein 38 in Serotonergic Neurons in the Brain of Nile Tilapia,Frontiers in neuroanatomy · 2018Article
- Systemic Treatment Strategies for Patients with Hereditary Breast Cancer Syndromes.The oncologist · 2017Review
- RING Finger Protein 38 Is a Neuronal Protein in the Brain of Nile Tilapia,Frontiers in neuroanatomy · 2017Article
- FANCJ at the FORK.Mutation research · 2016Review
- Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report.Journal of assisted reproduction and genetics · 2014Article
- Genetic variations of BRCA1 and BRCA2 genes in dogs with mammary tumours.Veterinary research communications · 2014Article
- Article
- Integrating genomics and proteomics data to predict drug effects using binary linear programming.PloS one · 2014Article
- Defining molecular and cellular responses after low and high linear energy transfer radiations to develop biomarkers of carcinogenic risk or therapeutic outcome.Health physics · 2012Review
- Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation.Cell cycle (Georgetown, Tex.) · 2012Article
- Mfd is required for rapid recovery of transcription following UV-induced DNA damage but not oxidative DNA damage in Escherichia coli.Journal of bacteriology · 2012Article
- Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment.International journal of surgical oncology · 2012Article
- Transgenic and knockout mice models to reveal the functions of tumor suppressor genes.Clinical Medicine Insights. Oncology · 2011Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2003-06-13Falsification/Fabrication of Data · Falsification/Fabrication of Image · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · Objections by Author(s) · · NIH Finding of misconduct for Steven A Leadon 6/9/2006; 2/10/2017
- Commented on by
- RetractedRetraction.2003
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The breast and ovarian cancer susceptibility gene BRCA1 encodes a zinc finger protein of unknown function. Association of the BRCA1 protein with the DNA repair protein Rad51 and changes in the phosphorylation and cellular localization of the protein after exposure to DNA-damaging agents are consistent with a role for BRCA1 in DNA repair. Here, it is shown that mouse embryonic stem cells deficient in BRCA1 are defective in the ability to carry out transcription-coupled repair of oxidative DNA damage, and are hypersensitive to ionizing radiation and hydrogen peroxide. These results suggest that BRCA1 participates, directly or indirectly, in transcription-coupled repair of oxidative DNA damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.