ArticleJournal of cell science1998
Depolarization of the actin cytoskeleton is a specific phenotype in Saccharomyces cerevisiae.
Article in Journal of cell science, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Exploring the role of cell cycle regulation in human mature adipocyte dedifferentiation.Frontiers in cell and developmental biology · 2025Article
- Improved tools for live imaging of F-actin structures in yeast.Molecular biology of the cell · 2024Article
- Actin dynamics in protein homeostasis.Bioscience reports · 2022Review
- Predicting gene phenotype by multi-label multi-class model based on essential functional features.Molecular genetics and genomics : MGG · 2021Article
- FgFim, a key protein regulating resistance to the fungicide JS399-19, asexual and sexual development, stress responses and virulence in Fusarium graminearum.Molecular plant pathology · 2014Article
- Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway.Molecular biology of the cell · 2007Article
- Rapid depletion of mutant eukaryotic initiation factor 5A at restrictive temperature reveals connections to actin cytoskeleton and cell cycle progression.Molecular genetics and genomics : MGG · 2006Article
- Pn-AMP1, a plant defense protein, induces actin depolarization in yeasts.Plant & cell physiology · 2004Article
- Yeast actin patches are networks of branched actin filaments.The Journal of cell biology · 2004Article
- A role for GEA1 and GEA2 in the organization of the actin cytoskeleton in Saccharomyces cerevisiae.Genetics · 2003Article
- The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation.Molecular and cellular biology · 2002Article
- Role of actin and Myo2p in polarized secretion and growth of Saccharomyces cerevisiae.Molecular biology of the cell · 2000Article
- The yeast GRD20 gene is required for protein sorting in the trans-Golgi network/endosomal system and for polarization of the actin cytoskeleton.Molecular biology of the cell · 1999Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
The yeast actin cytoskeleton is polarized during most of the cell cycle. Certain environmental factors and mutations are associated with depolarization of the actin cytoskeleton. Is depolarization of the actin cytoskeleton a specific response, or is it a nonspecific reaction to harsh conditions or poor metabolism? If depolarization is a nonspecific response, then any mutation that slows growth should induce depolarization. In addition, the number of genes with the depolarization phenotype should constitute a relatively large part of the genome. To address this question, we determined the effect of slow growth on the actin cytoskeleton, and we determined the frequency of mutations that affect the actin cytoskeleton. Eight mutants with slow growth showed no defect in actin polarization, indicating that slow growth alone is not sufficient to cause depolarization. Among 273 viable haploids disrupted for ORFs of chromosome I and VIII and 950 viable haploids with random genome disruptions, none had depolarization of the cytoskeleton. We conclude that depolarization of the actin cytoskeleton is a specific phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.