ArticleRNA (New York, N.Y.)1998
Destabilizing effect of an rRNA stem-loop on an attenuator hairpin in the 5' exon of the Tetrahymena pre-rRNA.
Article in RNA (New York, N.Y.), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
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- Single-nucleotide control of tRNA folding cooperativity under near-cellular conditions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Bridging the gap between in vitro and in vivo RNA folding.Quarterly reviews of biophysics · 2016Article
- Mss116p: a DEAD-box protein facilitates RNA folding.RNA biology · 2013Review
- Dual roles for the Mss116 cofactor during splicing of the ai5γ group II intron.Nucleic acids research · 2010Article
- The human HDV-like CPEB3 ribozyme is intrinsically fast-reacting.Biochemistry · 2010Article
- A conformational switch in the DiGIR1 ribozyme involved in release and folding of the downstream I-DirI mRNA.RNA (New York, N.Y.) · 2009Article
- A pH-jump approach for investigating secondary structure refolding kinetics in RNA.Nucleic acids research · 2002Article
- Coupled nucleotide covariations reveal dynamic RNA interaction patterns.RNA (New York, N.Y.) · 2000Review
- Refolding of rRNA exons enhances dissociation of the Tetrahymena intron.RNA (New York, N.Y.) · 2000Article
- Metastable structures and refolding kinetics in hok mRNA of plasmid R1.RNA (New York, N.Y.) · 1999Article
- In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity.RNA (New York, N.Y.) · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Self-splicing of the Tetrahymena group I intron is attenuated by an rRNA stem-loop in the 5' exon, which competes with formation of the P1 splice site helix. The equilibrium between the P1 and P(-1) stem-loops is influenced by rRNA sequences upstream and downstream of the intron. To investigate the mechanism of this conformational switch, internal deletions and point mutations were introduced in the second rRNA stem-loop upstream of the 5' splice site. Nuclease protection, native gel electrophoresis, and self-splicing results show that this helix is important for maintaining self-splicing activity. Co-axial base stacking of adjacent helices in the 5' exon is proposed to enable exchange between inactive and active conformations of the pre-rRNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.