ArticleThe Journal of cell biology1998
alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.
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Who cites it
137 citing papers in PubMed.
- Localization of cadherins in the postnatal cochlear epithelium and their relation to space formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Dynamics and functions of E-cadherin complexes in epithelial cell and tissue morphogenesis.Marine life science & technology · 2023Review
- Mechanotransduction: Forcing a change in metabolism.Current opinion in cell biology · 2023Review
- Vinculin Y822 is an important determinant of ligand binding.Journal of cell science · 2023Article
- Actin polymerization and depolymerization in developing vertebrates.Frontiers in physiology · 2023Review
- Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division.Journal of developmental biology · 2022Review
- Appropriate tension sensitivity of α-catenin ensures rounding morphogenesis of epithelial spheroids.Cell structure and function · 2022Article
- Tricellulin secures the epithelial barrier at tricellular junctions by interacting with actomyosin.The Journal of cell biology · 2022Article
- Understanding the molecular basis of cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2022Review
- Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin.Journal of cell science · 2021Article
- Tsc1 regulates tight junction independent of mTORC1.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Specific substrates composed of collagen and fibronectin support the formation of epithelial cell sheets by MDCK cells lacking α-catenin or classical cadherins.Cell and tissue research · 2021Article
- Cytoskeletal Organization and Cell Polarity in the Pathogenesis of Crohn's Disease.Clinical reviews in allergy & immunology · 2021Review
- The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain.International journal of molecular sciences · 2021Article
- Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction-Based Barrier Function Regulation.Biomolecules · 2020Review
- Walking the tight wire between cell adhesion and WNT signalling: a balancing act for β-catenin.Open biology · 2020Review
- Adherens junction regulates cryptic lamellipodia formation for epithelial cell migration.The Journal of cell biology · 2020Article
- The desmosome as a model for lipid raft driven membrane domain organization.Biochimica et biophysica acta. Biomembranes · 2020Review
- The multifarious regulation of the apical junctional complex.Open biology · 2020Review
- Super-Resolution Imaging of Tight and Adherens Junctions: Challenges and Open Questions.International journal of molecular sciences · 2020Review
77 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
alphaE-catenin, a cadherin-associated protein, is required for tight junction (TJ) organization, but its role is poorly understood. We transfected an alphaE-catenin-deficient colon carcinoma line with a series of alphaE-catenin mutant constructs. The results showed that the amino acid 326-509 domain of this catenin was required to organize TJs, and its COOH-terminal domain was not essential for this process. The 326-509 internal domain was found to bind vinculin. When an NH2-terminal alphaE-catenin fragment, which is by itself unable to organize the TJ, was fused with the vinculin tail, this chimeric molecule could induce TJ assembly in the alphaE-catenin-deficient cells. In vinculin-null F9 cells, their apical junctional organization was impaired, and this phenotype was rescued by reexpression of vinculin. These results indicate that the alphaE-catenin-vinculin interaction plays a role in the assembly of the apical junctional complex in epithelia.
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