ArticleThe Journal of cell biology1998
Regulation of organelle movement in melanophores by protein kinase A (PKA), protein kinase C (PKC), and protein phosphatase 2A (PP2A).
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 91 citations in OpenAlex.
- Article
- Melatonin effects on animal behavior: circadian rhythm, stress response, and modulation of behavioral patterns.Journal of animal science and technology · 2025Review
- Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation.International journal of molecular sciences · 2022Article
- Phosphoregulation of Kinesins Involved in Long-Range Intracellular Transport.Frontiers in cell and developmental biology · 2022Review
- From extraocular photoreception to pigment movement regulation: a new control mechanism of the lanternshark luminescence.Scientific reports · 2020Article
- Research Techniques Made Simple: Cell Biology Methods for the Analysis of Pigmentation.The Journal of investigative dermatology · 2020Review
- miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A.Oncotarget · 2017Article
- Myosin Va's adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles.Cold Spring Harbor perspectives in biology · 2017Review
- Bidirectional cargo transport: moving beyond tug of war.Nature reviews. Molecular cell biology · 2014Review
- PKA-dependent dynein switching from lysosomes to adenovirus: a novel form of host-virus competition.The Journal of cell biology · 2014Article
- CK1 activates minus-end-directed transport of membrane organelles along microtubules.Molecular biology of the cell · 2011Article
- Statistics of active transport in Xenopus melanophores cells.Biophysical journal · 2010Article
- Phosphorylation controls autoinhibition of cytoplasmic linker protein-170.Molecular biology of the cell · 2010Article
- The protein kinase A-anchoring protein moesin is bound to pigment granules in melanophores.Traffic (Copenhagen, Denmark) · 2009Article
- Cholesterol level regulates endosome motility via Rab proteins.Biophysical journal · 2008Article
- Carbachol-mediated pigment granule dispersion in retinal pigment epithelium requires Ca2+ and calcineurin.BMC cell biology · 2007Article
- Rab32 regulates melanosome transport in Xenopus melanophores by protein kinase a recruitment.Current biology : CB · 2007Article
- Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus.The EMBO journal · 2001Article
- Dynein, dynactin, and kinesin II's interaction with microtubules is regulated during bidirectional organelle transport.The Journal of cell biology · 2000Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We used melanophores, cells specialized for regulated organelle transport, to study signaling pathways involved in the regulation of transport. We transfected immortalized Xenopus melanophores with plasmids encoding epitope-tagged inhibitors of protein phosphatases and protein kinases or control plasmids encoding inactive analogues of these inhibitors. Expression of a recombinant inhibitor of protein kinase A (PKA) results in spontaneous pigment aggregation. alpha-Melanocyte-stimulating hormone (MSH), a stimulus which increases intracellular cAMP, cannot disperse pigment in these cells. However, melanosomes in these cells can be partially dispersed by PMA, an activator of protein kinase C (PKC). When a recombinant inhibitor of PKC is expressed in melanophores, PMA-induced pigment dispersion is inhibited, but not dispersion induced by MSH. We conclude that PKA and PKC activate two different pathways for melanosome dispersion. When melanophores express the small t antigen of SV-40 virus, a specific inhibitor of protein phosphatase 2A (PP2A), aggregation is completely prevented. Conversely, overexpression of PP2A inhibits pigment dispersion by MSH. Inhibitors of protein phosphatase 1 and protein phosphatase 2B (PP2B) do not affect pigment movement. Therefore, melanosome aggregation is mediated by PP2A.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.