ArticleThe Journal of cell biology1998
Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 121 citations in OpenAlex.
- The vacuole shapes the nucleus and the ribosomal DNA loop during mitotic delays.Life science alliance · 2022Article
- Article
- Endosomal trafficking of yeast membrane proteins.Biochemical Society transactions · 2018Review
- Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.Nature communications · 2018Article
- Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence.Journal of cell science · 2018Article
- Membrane protein recycling from the vacuole/lysosome membrane.The Journal of cell biology · 2018Article
- Phylogenetic Analysis of the vesicular fusion SNARE machinery revealing its functional divergence across Eukaryotes.Bioinformation · 2018Article
- PI5P and PI(3,5)PCell structure and function · 2017Review
- Multiple ER-Golgi SNARE transmembrane domains are dispensable for trafficking but required for SNARE recycling.Molecular biology of the cell · 2016Article
- Organelle Size Scaling of the Budding Yeast Vacuole by Relative Growth and Inheritance.Current biology : CB · 2016Article
- Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time.Biochemical Society transactions · 2016Review
- The ArfGAP2/3 Glo3 and ergosterol collaborate in transport of a subset of cargoes.Biology open · 2015Article
- Organelle size scaling of the budding yeast vacuole is tuned by membrane trafficking rates.Biophysical journal · 2014Article
- Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Architectural remodeling of the tonoplast during fluid-phase endocytosis.Plant signaling & behavior · 2013Article
- Vid28 protein is required for the association of vacuole import and degradation (Vid) vesicles with actin patches and the retention of Vid vesicle proteins in the intracellular fraction.The Journal of biological chemistry · 2013Article
- Vps34p is required for the decline of extracellular fructose-1,6-bisphosphatase in the vacuole import and degradation pathway.The Journal of biological chemistry · 2012Article
- Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P.The EMBO journal · 2012Article
- A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology.PloS one · 2011Article
- Vps-C complexes: gatekeepers of endolysosomal traffic.Current opinion in cell biology · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A large number of trafficking steps occur between the last compartment of the Golgi apparatus (TGN) and the vacuole of the yeast Saccharomyces cerevisiae. To date, two intracellular routes from the TGN to the vacuole have been identified. Carboxypeptidase Y (CPY) travels through a prevacuolar/endosomal compartment (PVC), and subsequently on to the vacuole, while alkaline phosphatase (ALP) bypasses this compartment to reach the same organelle. Proteins resident to the TGN achieve their localization despite a continuous flux of traffic by continually being retrieved from the distal PVC by virtue of an aromatic amino acid-containing sorting motif. In this study we report that a hybrid protein based on ALP and containing this retrieval motif reaches the PVC not by following the CPY sorting pathway, but instead by signal-dependent retrograde transport from the vacuole, an organelle previously thought of as a terminal compartment. In addition, we show that a mutation in VAC7, a gene previously identified as being required for vacuolar inheritance, blocks this trafficking step. Finally we show that Vti1p, a v-SNARE required for the delivery of both CPY and ALP to the vacuole, uses retrograde transport out of the vacuole as part of its normal cellular itinerary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.