ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Timing of dense-core vesicle exocytosis depends on the facilitation L-type Ca channel in adrenal chromaffin cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Action Potential Firing Patterns Regulate Dopamine Release via Voltage-Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Basal and Stress-Induced Network Activity in the Adrenal MedullaFrontiers in endocrinology · 2022Article
- CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- NMDA receptors potentiate activity-dependent dendritic release of neuropeptides from hypothalamic neurons.The Journal of physiology · 2019Article
- PKC enhances the capacity for secretion by rapidly recruiting covert voltage-gated Ca2+ channels to the membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Electroporation followed by electrochemical measurement of quantal transmitter release from single cells using a patterned microelectrode.Lab on a chip · 2013Article
- Article
- Physiology of quantal norepinephrine release from somatodendritic sites of neurons in locus coeruleus.Frontiers in molecular neuroscience · 2012Article
- Action potential bursts enhance transmitter release at a giant central synapse.The Journal of physiology · 2011Article
- Action potential modulates Ca2+-dependent and Ca2+-independent secretion in a sensory neuron.Biophysical journal · 2009Article
- Imaging of evoked dense-core-vesicle exocytosis in hippocampal neurons reveals long latencies and kiss-and-run fusion events.Journal of cell science · 2009Article
- Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Double patch clamp reveals that transient fusion (kiss-and-run) is a major mechanism of secretion in calf adrenal chromaffin cells: high calcium shifts the mechanism from kiss-and-run to complete fusion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Molecular identification and reconstitution of depolarization-induced exocytosis monitored by membrane capacitance.Biophysical journal · 2005Article
- Block of a Ca(2+)-activated potassium channel by cocaine.The Journal of membrane biology · 2005Article
- Calcium influx through hyperpolarization-activated cation channels (I(h) channels) contributes to activity-evoked neuronal secretion.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Control of secretion by temporal patterns of action potentials in adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Pituitary control of BK potassium channel function and intrinsic firing properties of adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- All classes of calcium channel couple with equal efficiency to exocytosis in rat melanotropes, inducing linear stimulus-secretion coupling.The Journal of physiology · 2000Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secretion from dense-core vesicles is reputedly much slower than that from typical synaptic vesicles, possibly because of noncolocalization of Ca channels and release sites. We reinvestigated this question by measuring the kinetics of catecholamine release in chromaffin cells from calf and adult bovines. Amperometric recording from calf chromaffin cells stimulated by action potentials exhibited two latencies of secretion that depended on both the frequency of stimulation and the pathway of Ca entry. Short-latency responses (<25 msec delay; "strongly coupled") appeared at low (0.25 and 1 Hz) and high (7 Hz) frequencies and were entirely dependent on recruitment of "facilitation" L-type Ca channels as revealed by nisoldipine blockade. Long-latency responses (>25 msec delay; "weakly coupled") were more apparent at higher frequencies (7 Hz) and were substantially reduced by toxins that blocked N- and P-type Ca channels. Ca current recordings revealed that adult bovine chromaffin cells lack facilitation channels; virtually all secretion was weakly coupled in these cells. The mean delay of the strongly coupled signal was approximately 3 msec after the peak of the action potential (at 24 degreesC), indicating that dense-core vesicles can exhibit a rate of exocytosis approaching that occurring in neurons. Although other explanations are possible, these results are consistent with the idea that facilitation Ca channels are colocalized with release sites in calf chromaffin cells. Calculations based on a model incorporating this assumption suggest that these channels must be within 13 nm of secretory sites to account for such rapid exocytosis.
Indexed as
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9698316PMC6793173What OpenQuestion holds
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