ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 136 citations in OpenAlex.
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- The substrate import mechanism of the human serotonin transporter.Biophysical journal · 2022Article
- Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology.Advances in experimental medicine and biology · 2021Review
- Regulation of Glutamate, GABA and Dopamine Transporter Uptake, Surface Mobility and Expression.Frontiers in cellular neuroscience · 2021Review
- Serotonin and serotonin transport in the regulation of lactation.Journal of mammary gland biology and neoplasia · 2014Review
- Opioid and GABAB receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment.Frontiers in pharmacology · 2014Article
- Plasticity of GABA transporters: an unconventional route to shape inhibitory synaptic transmission.Frontiers in cellular neuroscience · 2014Article
- Structure, function, and plasticity of GABA transporters.Frontiers in cellular neuroscience · 2014Review
- A TRP among the astrocytes.The Journal of physiology · 2013Review
- The solute carrier 6 family of transporters.British journal of pharmacology · 2012Review
- Association of GTF2i in the Williams-Beuren syndrome critical region with autism spectrum disorders.Journal of autism and developmental disorders · 2012Article
- Vesicular and plasma membrane transporters for neurotransmitters.Cold Spring Harbor perspectives in biology · 2012Review
- Inhibition of Activity of GABA Transporter GAT1 by δ-Opioid Receptor.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Syntaxin 1A regulates dopamine transporter activity, phosphorylation and surface expression.Neuroscience · 2010Article
- The N terminus of monoamine transporters is a lever required for the action of amphetamines.The Journal of biological chemistry · 2010Article
- Regulation of dopamine transporter activity by carboxypeptidase E.Molecular brain · 2009Article
- Calcium/calmodulin-dependent kinase II regulates the interaction between the serotonin transporter and syntaxin 1A.Neuropharmacology · 2008Article
- Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux.Molecular pharmacology · 2008Article
- Going with the flow: trafficking-dependent and -independent regulation of serotonin transport.Traffic (Copenhagen, Denmark) · 2008Review
- GABA uptake by purified avian Müller glia cells in culture.Neurotoxicity research · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Syntaxin 1A inhibits GABA uptake of an endogenous GABA transporter in neuronal cultures from rat hippocampus and in reconstitution systems expressing the cloned rat brain GABA transporter GAT1. Evidence of interactions between syntaxin 1A and GAT1 comes from three experimental approaches: botulinum toxin cleavage of syntaxin 1A, syntaxin 1A antisense treatments, and coimmunoprecipitation of a complex containing GAT1 and syntaxin 1A. Protein kinase C (PKC), shown previously to modulate GABA transporter function, exerts its modulatory effects by regulating the availability of syntaxin 1A to interact with the transporter, and a transporter mutant that fails to interact with syntaxin 1A is not regulated by PKC. These results suggest a new target for regulation by syntaxin 1A and a novel mechanism for controlling the machinery involved in both neurotransmitter release and reuptake.
Indexed as
Identifiers
9698305PMC6793212W2110910879What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.