ArticleClinical and experimental immunology1998
IL-10 up-regulates nitric oxide (NO) synthesis by lipopolysaccharide (LPS)-activated macrophages: improved control of Trypanosoma cruzi infection.
Article in Clinical and experimental immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome.Heart (British Cardiac Society) · 2008Trial
- Myeloid cell-derived PROS1 inhibits tumor metastasis by regulating inflammatory and immune responses via IL-10.The Journal of clinical investigation · 2021Article
- IL-10 treatment decreases blood pressure in male, but not female, spontaneously hypertensive rats.American journal of physiology. Renal physiology · 2020Article
- Loss of myeloid-specific protein phosphatase 2A enhances lung injury and fibrosis and results in IL-10-dependent sensitization of epithelial cell apoptosis.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected with Histoplasma capsulatum.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors.Journal of leukocyte biology · 2014Article
- Metallothionein-1 and nitric oxide expression are inversely correlated in a murine model of Chagas disease.Memorias do Instituto Oswaldo Cruz · 2014Article
- Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred Up by Interferons?Frontiers in immunology · 2013Article
- IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Interleukin-10 inhibits the in vivo and in vitro adverse effects of TNF-alpha on the endothelium of murine aorta.American journal of physiology. Heart and circulatory physiology · 2010Article
- Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages.Journal of leukocyte biology · 2009Review
- Interleukin-10 promotes pathological angiogenesis by regulating macrophage response to hypoxia during development.PloS one · 2008Article
- Malnutrition alters the innate immune response and increases early visceralization following Leishmania donovani infection.Infection and immunity · 2001Article
- Benznidazole, a drug employed in the treatment of Chagas' disease, down-regulates the synthesis of nitrite and cytokines by murine stimulated macrophages.Clinical and experimental immunology · 1999Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the effects of IL-10 on tumour necrosis factor-alpha (TNF-alpha) and NO production by LPS-activated macrophages and on the ability of these cells to control Trypanosoma cruzi infection. We first observed that the addition of rIL-10 to macrophages of the J774 cell line decreased their synthesis of TNF-alpha but increased their release of NO in a dose-dependent manner. In parallel, treatment of J774 cells with rIL-10 resulted in a better control of T. cruzi infection involving up-regulation of NO synthesis, as it was not observed in presence of N-nitro-L-arginine methyl ester (L-NAME), a competitive inhibitor of NO synthase. The enhancing effect of rIL-10 on NO production was not observed on peritoneal macrophages from wild-type C57Bl/6 mice, but well on macrophages from IL-10 knock-out mice. The control of NO production by endogenous IL-10 was confirmed by the demonstration that neutralization of IL-10 secreted by LPS-activated macrophages from wild-type mice inhibited their production of NO and, in parallel, their ability to control T. cruzi infection. Taken together, these data demonstrate that both exogenous and endogenous IL-10 up-regulate the production of NO by LPS-activated macrophages and improve thereby their ability to clear T. cruzi infection.
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