ArticleCirculation1998
Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle.
Article in Circulation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02633488 (Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Effects ofFrontiers in pharmacology · 2022Pooled it
- Acute Sympathetic Blockade Improves Insulin-Mediated Microvascular Blood Flow in the Forearm of Adult Human Subjects With Obesity.Journal of the American Heart Association · 2024Trial
- Degree of Blood Pressure Control and Incident Diabetes Mellitus in Chinese Adults With Hypertension.Journal of the American Heart Association · 2020Trial
- Influence of glucose and insulin on transcapillary fluid absorption from the arm during lower body negative pressure in man.European journal of applied physiology · 2003Trial
- An acute crossover trial of passive movement training with and without blood flow restriction to determine the impact on postprandial glycaemia.Experimental physiology · 2026Article
- Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA-Brasil Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Clinical Value of ABCB1 and PAI-1 Gene Polymorphisms in Predicting Glucocorticoid-induced Adverse Reactions in Nephrotic Syndrome Patients.Current medical science · 2024Article
- Endothelial Function Assessed by Digital Volume Plethysmography Predicts the Development and Progression of Type 2 Diabetes Mellitus.Journal of the American Heart Association · 2019Article
- Rest-Stress Limb Perfusion Imaging in Humans with Contrast Ultrasound Using Intermediate-Power Imaging and Microbubbles Resistant to Inertial Cavitation.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2017Article
- Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion.Journal of visualized experiments : JoVE · 2017Article
- Human insulin dynamics in women: a physiologically based model.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Real-time contrast ultrasound muscle perfusion imaging with intermediate-power imaging coupled with acoustically durable microbubbles.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2015Article
- Insulin action in muscle and adipose tissue in type 2 diabetes: The significance of blood flow.World journal of diabetes · 2015Review
- Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells.Molecular biology of the cell · 2015Article
- Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume.American journal of physiology. Endocrinology and metabolism · 2014Article
- Relationships of serum soluble E-selectin concentration with insulin sensitivity and metabolic flexibility in lean and obese women.Endocrine · 2014Article
- The vascular endothelium, a benign restrictive barrier? NO! Role of nitric oxide in regulating insulin action.Diabetes · 2013Article
- Review
- Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates.American journal of physiology. Endocrinology and metabolism · 2012Article
- Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease.Current cardiovascular risk reports · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundConflicting evidence exists concerning whether insulin-induced vasodilation plays a mechanistic role in the regulation of limb glucose uptake. It can be predicted that if insulin augments blood flow by causing tissue recruitment, this mechanism would enhance limb glucose uptake. METHODS AND
resultsTwenty healthy subjects were studied with the forearm perfusion technique in combination with the euglycemic insulin clamp technique. Ten subjects were studied at physiological insulin concentrations (approximately 400 pmol/L) and the other 10 at supraphysiological insulin concentrations (approximately 5600 pmol/L). Four additional subjects underwent a saline control study. Pulse injections of a nonmetabolizable extracellular marker (1-[3H]-L-glucose) were administered into the brachial artery, and its washout curves were measured in one ipsilateral deep forearm vein and used to estimate the extracellular volume of distribution and hence the amount of muscle tissue drained by the deep forearm vein. Both during saline infusion and at physiological levels of hyperinsulinemia we observed no changes in blood flow and/or muscle tissue drained by the deep forearm vein. However, supraphysiological hyperinsulinemia accelerated total forearm blood flow (45.0+/-1.8 versus 36.5+/-1.3 mL x min(-1) x kg(-1), P<0.01) and increased the amount of muscle tissue drained by the deep forearm vein (305+/-46 versus 229+/-32 g, P<0.05). The amount of tissue newly recruited by insulin was strongly correlated to the concomitant increase in tissue glucose uptake (r=0.789, P<0.01).
conclusionsAcceleration of forearm blood flow mediated by supraphysiological hyperinsulinemia is accompanied by tissue recruitment, which may be a relevant determinant of forearm (muscle) glucose uptake.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.