ArticleJournal of virology1998
Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The Potential Role of Nitric Oxide as a Therapeutic Agent against SARS-CoV-2 Infection.International journal of molecular sciences · 2023Review
- Diverse roles of lung macrophages in the immune response to influenza A virus.Frontiers in microbiology · 2023Review
- Poxviruses package viral redox proteins in lateral bodies and modulate the host oxidative response.PLoS pathogens · 2022Article
- Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection.BioMed research international · 2017Article
- The role of myeloid cell activation and arginine metabolism in the pathogenesis of virus-induced diseases.Frontiers in immunology · 2014Review
- Beneficial actions of melatonin in the management of viral infections: a new use for this "molecular handyman"?Reviews in medical virology · 2012Review
- Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Clearance of HIV type 1 envelope recombinant sendai virus depends on CD4+ T cells and interferon-gamma but not B cells, CD8+ T cells, or perforin.AIDS research and human retroviruses · 2010Article
- Innate immune control and regulation of influenza virus infections.Journal of leukocyte biology · 2009Review
- Role of epithelial nitric oxide in airway viral infection.Free radical biology & medicine · 2006Review
- Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo.Journal of virology · 2005Article
- Poxvirus tropism.Nature reviews. Microbiology · 2005Review
- The role of IL-12, IL-23 and IFN-gamma in immunity to viruses.Cytokine & growth factor reviews · 2004Review
- Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.Journal of virology · 2001Article
- Nitric oxide and virus infection.Immunology · 2000Review
- Nitric oxide inhibits HIV tat-induced NF-kappaB activation.The American journal of pathology · 1999Article
- Interleukin-18 protects mice against acute herpes simplex virus type 1 infection.Journal of virology · 1999Article
- The interferon-inducible chemokines MuMig and Crg-2 exhibit antiviral activity In vivo.Journal of virology · 1999Article
- Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice.The Journal of experimental medicine · 1998Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminution in other well-characterized anti-EV immune responses, i.e. , gamma interferon secretion and NK cell and EV-specific cytotoxic T lymphocyte activities. Thus, the NOS2 locus can be considered a critical monogenic determinant of EV resistance that contributes to host survival.
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Registered trials
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