ArticleJournal of virology1998
CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 118 citations in OpenAlex.
- CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8BMC immunology · 2023Article
- Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model.Communications biology · 2023Article
- Mechanisms of CD40-dependent cDC1 licensing beyond costimulation.Nature immunology · 2022Article
- An autopsy case of fulminant myocarditis after severe acute respiratory syndrome coronavirus 2 vaccine inoculation.Pathology international · 2022Article
- Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model.PLoS pathogens · 2016Article
- Immunotherapy for human papillomavirus-associated disease and cervical cancer: review of clinical and translational research.Journal of gynecologic oncology · 2016Review
- Article
- Apoptosis in virus infection dynamics models.Journal of biological dynamics · 2014Article
- CD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseases.Critical reviews in immunology · 2013Article
- Vaccine-elicited CD8+ T cells protect against respiratory syncytial virus strain A2-line19F-induced pathogenesis in BALB/c mice.Journal of virology · 2012Article
- Dendritic cell activation and memory cell development are impaired among mice administered medroxyprogesterone acetate prior to mucosal herpes simplex virus type 1 infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- TriVax-HPV: an improved peptide-based therapeutic vaccination strategy against human papillomavirus-induced cancers.Cancer immunology, immunotherapy : CII · 2012Review
- CD40 ligand enhances immunogenicity of vector-based vaccines in immunocompetent and CD4+ T cell deficient individuals.Vaccine · 2012Article
- Article
- A prospective study of influenza vaccination and a comparison of immunologic parameters in children and adults with chromosome 22q11.2 deletion syndrome (digeorge syndrome/velocardiofacial syndrome).Journal of clinical immunology · 2011Article
- CD40 ligand deficiency: neurologic sequelae with radiographic correlation.Pediatric neurology · 2009Article
- Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge.Blood · 2008Article
- CD40-CD40 ligand interactions promote trafficking of CD8+ T cells into the brain and protection against West Nile virus encephalitis.Journal of virology · 2007Article
- Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function.The Journal of experimental medicine · 2007Article
- CD8 T cell memory development: CD4 T cell help is appreciated.Immunologic research · 2007Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
CD8(+) cytotoxic T lymphocytes (CTL) play a key role in the control of many virus infections, and the need for vaccines to elicit strong CD8(+) T-cell responses in order to provide optimal protection in such infections is increasingly apparent. However, the mechanisms involved in the induction and maintenance of CD8(+) CTL memory are currently poorly understood. In this study, we investigated the involvement of CD40 ligand (CD40L)-mediated interactions in these processes by analyzing the memory CTL response of CD40L-deficient mice following infection with lymphocytic choriomeningitis virus (LCMV). The maintenance of memory CD8(+) CTL precursors (CTLp) at stable frequencies over time was not impaired in CD40L-deficient mice. By contrast, the initial generation of memory CTLp was affected. CD40L-deficient mice produced lower levels of CD8(+) CTLp during the primary immune response to LCMV than did wild-type controls, despite the fact that the LCMV-specific effector CTL response of CD40L-deficient mice was indistinguishable from that of control animals. The differentiation of naïve CD8(+) T cells into effector and memory CTL thus involves pathways that can be discriminated from each other by their requirement for CD40L-mediated interactions. Expression of CD40L by CTLp themselves was not an essential step during their expansion and differentiation from naïve CD8(+) cells into memory CTLp; instead, the reduction in memory CTLp generation in CD40L-deficient mice was likely a consequence of defects in the CD4(+) T-cell response mounted by these animals. These results thus suggest a previously unappreciated role for CD40L in the generation of CD8(+) memory CTLp, the probable nature of which is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.