ArticleJournal of virology1998
The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Targeted mutagenesis of the ICP4 transactivation domain generates a protective DIVA vaccine against duck plague.Poultry science · 2026Article
- Nanopore sequencing and full genome de novo assembly of human cytomegalovirus TB40/E reveals clonal diversity and structural variations.BMC genomics · 2018Article
- Mitochondrial selfish elements and the evolution of biological novelties.Current zoology · 2016Article
- iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.ACS medicinal chemistry letters · 2016Article
- High-throughput analysis of human cytomegalovirus genome diversity highlights the widespread occurrence of gene-disrupting mutations and pervasive recombination.Journal of virology · 2015Article
- The intrinsic disorder alphabet. III. Dual personality of serine.Intrinsically disordered proteins · 2015Review
- Identification of B cells as a major site for cyprinid herpesvirus 3 latency.Journal of virology · 2014Article
- Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The N terminus and C terminus of herpes simplex virus 1 ICP4 cooperate to activate viral gene expression.Journal of virology · 2012Article
- A vitellogenin polyserine cleavage site: highly disordered conformation protected from proteolysis by phosphorylation.The Journal of experimental biology · 2012Article
- Genomic and functional characterization of the diverse immunoglobulin domain-containing protein (DICP) family.Genomics · 2012Article
- A wide extent of inter-strain diversity in virulent and vaccine strains of alphaherpesviruses.PLoS pathogens · 2011Article
- CK2 inhibitors increase the sensitivity of HSV-1 to interferon-β.Antiviral research · 2011Article
- Herpes simplex virus 1 ICP4 forms complexes with TFIID and mediator in virus-infected cells.Journal of virology · 2011Article
- Purification and characterisation of cell survival factor 1 (TCSF1) from Tetrahymena thermophila.Journal of cell communication and signaling · 2007Article
- DNA-dependent oligomerization of herpes simplex virus type 1 regulatory protein ICP4.Journal of virology · 2007Article
- ICP0 is not required for efficient stress-induced reactivation of herpes simplex virus type 1 from cultured quiescently infected neuronal cells.Journal of virology · 2006Article
- L-particle production during primary replication of pseudorabies virus in the nasal mucosa of swine.Journal of virology · 2003Article
- Repression of TFII-I-dependent transcription by nuclear exclusion.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Early expression of herpes simplex virus (HSV) proteins and reactivation of latent infection.Folia microbiologica · 2000Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
ICP4 of herpes simplex virus (HSV) is essential for productive infection due to its central role in the regulation of HSV transcription. This study identified a region of ICP4 that is not required for viral growth in culture or at the periphery of experimentally inoculated mice but is critical for productive growth in the trigeminal ganglia. This region of ICP4 encompasses amino acids 184 to 198 and contains 13 nearly contiguous serine residues that are highly conserved among the alphaherpesviruses. A mutant in which this region is deleted (DeltaSER) was able to grow on the corneas of mice and be transported back to the trigeminal ganglia. DeltaSER did not grow in the trigeminal ganglia but did express low levels of several immediate-early (ICP4 and ICP27) and early (thymidine kinase [tk] and UL42) genes. It expressed very low levels of the late gC gene and did not appear to replicate DNA. This pattern of gene expression was similar to that observed for a tk mutant, dlsptk. Both DeltaSER and dlsptk expressed higher levels of the latency-associated transcript (LAT) per genome earlier in infected ganglia than did the wild-type virus, KOS. However, infected ganglia from all three viruses accumulated the same level of LAT per genome at 30 days postinfection (during latency). The data suggest that the polyserine tract of ICP4 provides an activity that is required for lytic infection in ganglia to progress to viral DNA synthesis and full lytic gene expression. In the absence of this activity, higher levels of LAT per genome accumulate earlier in infection than with wild-type virus.
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