ArticleJournal of virology1998
Resistance to murine hepatitis virus strain 3 is dependent on production of nitric oxide.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Impact of Inhaled Nitric Oxide (iNO) on the Outcome of COVID-19 Associated ARDS.Journal of clinical medicine · 2024Article
- Assessment of nitric oxide (NO) potential to mitigate COVID-19 severity.Virusdisease · 2021Article
- Implications of SARS-Cov-2 infection on eNOS and iNOS activity: Consequences for the respiratory and vascular systems.Nitric oxide : biology and chemistry · 2021Review
- Combination Treatment With Remdesivir and Ivermectin Exerts Highly Synergistic and Potent Antiviral Activity Against Murine Coronavirus Infection.Frontiers in cellular and infection microbiology · 2021Article
- Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review.Viruses · 2020Review
- SARS-CoV-2: An Update on Potential Antivirals in Light of SARS-CoV Antiviral Drug Discoveries.Vaccines · 2020Review
- COVID-19: The Potential Role of Copper and N-acetylcysteine (NAC) in a Combination of Candidate Antiviral Treatments Against SARS-CoV-2.In vivo (Athens, Greece) · 2020Review
- Mouse Hepatitis Virus Infection Induces a Toll-Like Receptor 2-Dependent Activation of Inflammatory Functions in Liver Sinusoidal Endothelial Cells during Acute Hepatitis.Journal of virology · 2016Article
- CD4-CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation.Cellular immunology · 2012Article
- Proteasome inhibition in vivo promotes survival in a lethal murine model of severe acute respiratory syndrome.Journal of virology · 2010Article
- N-acetylpenicillamine inhibits the replication of porcine reproductive and respiratory syndrome virus in vitro.Veterinary research communications · 2010Article
- The Role of FGL2 in the Pathogenesis and Treatment of Hepatitis C Virus Infection.Rambam Maimonides medical journal · 2010Article
- Dual effect of nitric oxide on SARS-CoV replication: viral RNA production and palmitoylation of the S protein are affected.Virology · 2009Article
- Nitric oxide inhibits the replication cycle of porcine parvovirus in vitro.Archives of virology · 2009Article
- Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell line.Virology journal · 2007Article
- Association between nitric oxide synthesis and vaccination-acquired resistance to murine hepatitis virus by spf mice.Free radical biology & medicine · 2006Article
- Development of antiviral therapy for severe acute respiratory syndrome.Antiviral research · 2005Review
- Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus.Journal of virology · 2005Article
- Arginine metabolism during macrophage autocrine activation and infection with mouse hepatitis virus 3.Immunobiology · 2004Article
- Mitochondrial aconitase binds to the 3' untranslated region of the mouse hepatitis virus genome.Journal of virology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The strain-specific spectrum of liver disease following murine hepatitis virus type 3 (MHV-3) infection is dependent on inflammatory mediators released by macrophages. Production of nitric oxide (NO) by macrophages has been implicated in resistance to a number of viruses, including ectromelia virus, vaccinia virus, and herpes simplex virus type 1. This study was undertaken to define the role of NO in MHV-3 infection. Gamma interferon-induced production of NO inhibited growth of MHV-3 in a murine macrophage cell line (RAW 264.7). Viral inhibitory activity was reproduced by the NO donor S-nitroso-N-acetyl-DL-penicillamine (SNAP), whereas N-acetyl-DL-pencillamine (NAP), an inactive analog of SNAP, had no effect. Electron microscopy studies confirmed the inhibitory effects of NO on viral replication. Peritoneal macrophages isolated from A/J mice known to be resistant to MHV-3 produced a fivefold-higher level of NO and higher levels of mRNA transcripts of inducible NO synthase in response to gamma interferon than macrophages from susceptible BALB/cJ mice. SNAP inhibited growth of MHV-3 in macrophages from both strains of mice to similar degrees. In vivo inhibition of NO by N-monomethyl-L-arginine resulted in loss of resistance to MHV-3 in A/J mice. These results collectively demonstrate a defect in the production of NO in macrophages from susceptible BALB/cJ mice and define the importance of endogenous NO in resistance to MHV-3 infection in resistant A/J mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.