ArticleJournal of bacteriology1998
Regulation of hepA of Anabaena sp. strain PCC 7120 by elements 5' from the gene and by hepK.
Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A Phosphorylation-Dependent Partner-Switching-Like Module Regulates a Glycosyltransferase Required for Heterocyst Polysaccharide Layer Formation in Anabaena sp. Strain PCC 7120.Molecular microbiology · 2026Article
- Mutual interference of phosphorus starvation and diazotrophy in the cyanobacteria Nostoc sp. PCC 7120.Protoplasma · 2026Article
- Functional Overlap ofJournal of bacteriology · 2018Article
- The composition of the global and feature specific cyanobacterial core-genomes.Frontiers in microbiology · 2015Article
- Expanding the direct HetR regulon in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2014Article
- Identification of the HetR recognition sequence upstream of hetZ in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2012Article
- Cyanobacterial heterocysts.Cold Spring Harbor perspectives in biology · 2010Review
- Predicted glycosyl transferase genes located outside the HEP island are required for formation of heterocyst envelope polysaccharide in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2007Article
- Mutations in four regulatory genes have interrelated effects on heterocyst maturation in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2006Article
- Signal transduction genes required for heterocyst maturation in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2006Article
- Inhibition of cell division suppresses heterocyst development in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2006Article
- Regulation by hetC of genes required for heterocyst differentiation and cell division in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2005Article
- Anabaena sp. strain PCC 7120 gene devH is required for synthesis of the heterocyst glycolipid layer.Journal of bacteriology · 2005Article
- Clustered genes required for the synthesis of heterocyst envelope polysaccharide in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2005Article
- patS minigenes inhibit heterocyst development of Anabaena sp. strain PCC 7120.Journal of bacteriology · 2004Article
- HetR homodimer is a DNA-binding protein required for heterocyst differentiation, and the DNA-binding activity is inhibited by PatS.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- hetL overexpression stimulates heterocyst formation in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2002Article
- Novel DNA-binding proteins in the cyanobacterium Anabaena sp. strain PCC 7120.Journal of bacteriology · 2002Article
- HcwA, an autolysin, is required for heterocyst maturation in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2001Article
- PatS and products of nitrogen fixation control heterocyst pattern.Journal of bacteriology · 2001Article
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3 authors.
Funding
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Abstract
In Anabaena spp., synthesis of the heterocyst envelope polysaccharide, required if the cell is to fix dinitrogen under aerobic conditions, is dependent on the gene hepA. A transcriptional start site of hepA was localized 104 bp 5' from its translational initiation codon. A 765-bp open reading frame, denoted hepC, was found farther upstream. Inactivation of hepC led to constitutive expression of hepA and prevented the synthesis of heterocyst envelope polysaccharide. However, the glycolipid layer of the heterocyst envelope was synthesized. A hepK mutation blocked both the synthesis of the heterocyst envelope polysaccharide and induction of hepA. The predicted product of hepK resembles a sensory protein-histidine kinase of a two-component regulatory system. Analysis of the region between hepC and hepA indicated that DNA sequences required for the induction of hepA upon nitrogen deprivation are present between bp -574 and -440 and between bp -340 and -169 relative to the transcriptional start site of hepA. Gel mobility shift assays provided evidence that one or more proteins bind specifically to the latter sequence. The Fox box sequence downstream from hepA appeared inessential for the induction of hepA.
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