ArticleGenes & development1998
Distinct C/EBP functions are required for eosinophil lineage commitment and maturation.
Article in Genes & development, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 120 citations in OpenAlex.
- Eosinophil biology in COPD: from scientific insight to clinical treatment action.ERJ open research · 2026Review
- Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish.Nature communications · 2024Article
- Origins and functions of eosinophils in two non-mucosal tissues.Frontiers in immunology · 2024Review
- Eosinophils in obesity and obesity-associated disorders.Discovery immunology · 2023Review
- Aiolos regulates eosinophil migration into tissues.Mucosal immunology · 2021Article
- Article
- Transcriptional Regulation of Cancer Immune Checkpoints: Emerging Strategies for Immunotherapy.Vaccines · 2020Review
- Transcription factor and cytokine regulation of eosinophil lineage commitment.Current opinion in hematology · 2020Review
- Revealing the Critical Regulators of Cell Identity in the Mouse Cell Atlas.Cell reports · 2018Article
- Transcription Factors in Eosinophil Development and As Therapeutic Targets.Frontiers in medicine · 2017Review
- Eosinophils and Mast Cells in Aspirin-Exacerbated Respiratory Disease.Immunology and allergy clinics of North America · 2016Review
- Lung-resident eosinophils represent a distinct regulatory eosinophil subset.The Journal of clinical investigation · 2016Article
- The Eosinophil in Health and Disease: from Bench to Bedside and Back.Clinical reviews in allergy & immunology · 2016Review
- Eosinophils in infection and intestinal immunity.Current opinion in gastroenterology · 2013Review
- Lymphoid to myeloid cell trans-differentiation is determined by C/EBPβ structure and post-translational modifications.PloS one · 2013Article
- Eosinophil development, regulation of eosinophil-specific genes, and role of eosinophils in the pathogenesis of asthma.Allergy, asthma & immunology research · 2012Article
- Eosinophil survival and apoptosis in health and disease.Allergy, asthma & immunology research · 2010Article
- The TLR1/2 agonist PAM(3)CSK(4) instructs commitment of human hematopoietic stem cells to a myeloid cell fate.Leukemia · 2009Article
- Motif discovery in promoters of genes co-localized and co-expressed during myeloid cells differentiation.Nucleic acids research · 2009Article
- Biology of the eosinophil.Advances in immunology · 2009Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Hematopoietic differentiation involves the commitment of multipotent progenitors to a given lineage, followed by the maturation of the committed cells. To study the transcriptional events controlling these processes, we have investigated the role of C/EBP proteins in lineage choice of multipotent hematopoietic progenitors (MEPs) transformed by the E26 virus. We found that forced expression of either the alpha or beta isoforms of C/EBP in MEPs induced eosinophil differentiation and that in addition, C/EBPbeta could induce myeloid differentiation. Conversely, dominant-negative versions of C/EBPbeta inhibited myeloid differentiation. C/EBP-induced eosinophil differentiation could be separated into two distinct events, lineage commitment and maturation. Thus, eosinophils induced by transactivation-deficient C/EBPbeta alleles were found to be blocked in their maturation, whereas those expressing wild-type C/EBP proteins were not. Likewise, a 1-day activation of a conditional C/EBPbeta allele in multipotent progenitors led to the formation of immature eosinophils, whereas sustained activation produced mature eosinophils. These results show that C/EBP can induce both myeloid and eosinophil lineage commitment and that transactivation independent and dependent C/EBP functions are required during eosinophil lineage commitment and maturation, respectively.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.