ArticleMolecular biology of the cell1998
Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq/11, G-protein receptor kinase-2/3, and beta-arrestin-1/2.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 91 citations in OpenAlex.
- Neurokinin-1 receptor desensitization to consecutive microdialysis infusions of substance P in human skin.The Journal of physiology · 2005Trial
- Mast Cells and Substance P: Neuroinflammatory Loops at the Molecular and Translational Clinical Levels.Biomolecules · 2026Review
- Nucleus accumbens local circuit for cue-dependent aversive learning.Cell reports · 2023Article
- Immunomodulatory Role of Neuropeptides in the Cornea.Biomedicines · 2022Review
- Roles of Neuropeptides in Sleep-Wake Regulation.International journal of molecular sciences · 2022Review
- MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis.Cell proliferation · 2019Article
- A Chitosan-Based Liposome Formulation Enhances the In Vitro Wound Healing Efficacy of Substance P Neuropeptide.Pharmaceutics · 2017Article
- Sleep-inducing effect of substance P-cholera toxin A subunit in mice.Neuroscience letters · 2017Article
- Neuropeptide substance P and the immune response.Cellular and molecular life sciences : CMLS · 2016Review
- G Protein-Coupled Receptor Trafficking and Signalling in the Enteric Nervous System: The Past, Present and Future.Advances in experimental medicine and biology · 2016Review
- Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.The Journal of biological chemistry · 2013Article
- An indirect role for oncomir-519b in the expression of truncated neurokinin-1 in breast cancer cells.Experimental cell research · 2012Article
- Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species.Frontiers in neural circuits · 2012Article
- Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones.The Journal of physiology · 2011Article
- Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.The Journal of biological chemistry · 2009Article
- Activation of neurokinin 3 receptor increases Na(v)1.9 current in enteric neurons.The Journal of physiology · 2009Article
- Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation.British journal of pharmacology · 2009Article
- Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Imaging of muscarinic acetylcholine receptor signaling in hippocampal neurons: evidence for phosphorylation-dependent and -independent regulation by G-protein-coupled receptor kinases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats.The Journal of physiology · 2003Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Observations in reconstituted systems and transfected cells indicate that G-protein receptor kinases (GRKs) and beta-arrestins mediate desensitization and endocytosis of G-protein-coupled receptors. Little is known about receptor regulation in neurons. Therefore, we examined the effects of the neurotransmitter substance P (SP) on desensitization of the neurokinin-1 receptor (NK1-R) and on the subcellular distribution of NK1-R, Galphaq/11, GRK-2 and -3, and beta-arrestin-1 and -2 in cultured myenteric neurons. NK1-R was coexpressed with immunoreactive Galphaq/11, GRK-2 and -3, and beta-arrestin-1 and -2 in a subpopulation of neurons. SP caused 1) rapid NK1-R-mediated increase in [Ca2+]i, which was transient and desensitized to repeated stimulation; 2) internalization of the NK1-R into early endosomes containing SP; and 3) rapid and transient redistribution of beta-arrestin-1 and -2 from the cytosol to the plasma membrane, followed by a striking redistribution of beta-arrestin-1 and -2 to endosomes containing the NK1-R and SP. In SP-treated neurons Galphaq/11 remained at the plasma membrane, and GRK-2 and -3 remained in centrally located and superficial vesicles. Thus, SP induces desensitization and endocytosis of the NK1-R in neurons that may be mediated by GRK-2 and -3 and beta-arrestin-1 and -2. This regulation will determine whether NK1-R-expressing neurons participate in functionally important reflexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.