ArticleThe Biochemical journal1998
alpha-Tocopherol specifically inactivates cellular protein kinase C alpha by changing its phosphorylation state.
Article in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 262 citations in OpenAlex.
- The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials.Scientific reports · 2020Pooled it
- Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.European journal of clinical nutrition · 2015Pooled it
- Comparative neuroprotective and antioxidant roles of vitamin E isoforms: a review.Journal of clinical biochemistry and nutrition · 2026Review
- Effects of Food Enrichment Based on Diverse Feeding Regimes on Growth, Immunity, and Stress Resistance ofAntioxidants (Basel, Switzerland) · 2025Article
- Nutritional Support of Chronic Obstructive Pulmonary Disease.Nutrients · 2025Review
- Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review.Immunity & ageing : I & A · 2025Review
- Alpha-tocopherol serum concentrations and its relationship with anthropometric, biochemical, dietary and cardiovascular risk parameters.Frontiers in nutrition · 2025Article
- α-Tocopherol inhibits atherogenesis and improves cardiac function in mice independently of its antioxidant properties.Vascular biology (Bristol, England) · 2024Article
- Metabolomic Alterations in Mammary Glands from Pubertal Mice Fed a High-Fat Diet.Nutrition and metabolic insights · 2023Article
- Review
- Article
- Evidence for Oxidative Pathways in the Pathogenesis of PD: Are Antioxidants Candidate Drugs to Ameliorate Disease Progression?International journal of molecular sciences · 2022Review
- Oxidized LDLs as Signaling Molecules.Antioxidants (Basel, Switzerland) · 2021Review
- The Relationship Between Nutrition and Atherosclerosis.Frontiers in bioengineering and biotechnology · 2021Review
- Vitamin E acetate as linactant in the pathophysiology of EVALI.Medical hypotheses · 2020Article
- Roles of vitamins in stem cells.Cellular and molecular life sciences : CMLS · 2020Review
- Table olives and health: a review.Journal of nutritional science · 2020Review
- Review
- The Effectiveness of Vitamin E Treatment in Alzheimer's Disease.International journal of molecular sciences · 2019Review
- The Role of the Status of Selected Micronutrients in Shaping the Immune Function.Endocrine, metabolic & immune disorders drug targets · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of protein kinase C (PKC) regulation by alpha-tocopherol has been investigated in smooth-muscle cells. Treatment of rat aortic A7r5 smooth-muscle cells with alpha-tocopherol resulted in a time- and dose-dependent inhibition of PKC. The inhibition was not related to a direct interaction of alpha-tocopherol with the enzyme nor with a diminution of its expression. Western analysis demonstrated the presence of PKCalpha, beta, delta, epsilon, zeta and micro isoforms in these cells. Autophosphorylation and kinase activities of the different isoforms have shown that only PKCalpha was inhibited by alpha-tocopherol. The inhibitory effects were not mimicked by beta-tocopherol, an analogue of alpha-tocopherol with similar antioxidant properties. The inhibition of PKCalpha by alpha-tocopherol has been found to be associated with its dephosphorylation. Moreover the finding of an activation of protein phosphatase type 2A in vitro by alpha-tocopherol suggests that this enzyme might be responsible for the observed dephosphorylation and subsequent deactivation of PKCalpha. It is therefore proposed that PKCalpha inhibition by alpha-tocopherol is linked to the activation of a protein phosphatase, which in turn dephosphorylates PKCalpha and inhibits its activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.