ArticleGut1998
Serum and liver HCV RNA levels in patients with chronic hepatitis C: correlation with clinical and histological features.
Article in Gut, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 107 citations in OpenAlex.
- The efficacy of integrated hepatitis C virus treatment in relieving fatigue in people who inject drugs: a randomized controlled trial.Substance abuse treatment, prevention, and policy · 2023Trial
- The Persistence of Hepatitis C Virus Infection in Hepatocytes Promotes Hepatocellular Carcinoma Progression by Pro-Inflammatory Interluekin-8 Expression.Biomedicines · 2021Article
- Impact of clinical and sociodemographic factors on fatigue among patients with substance use disorder: a cohort study from Norway for the period 2016-2020.Substance abuse treatment, prevention, and policy · 2020Article
- Reply.Gastroenterology · 2017Article
- The Impact of Enhanced Screening and Treatment on Hepatitis C in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Natural History of Hepatitis C.Gastroenterology clinics of North America · 2015Review
- Epidemiology and natural history of hepatitis C virus infection.World journal of gastroenterology · 2014Review
- Hepatitis C virus heterogeneity: lipoprotein and immunoglobulin binding and clinical status.Journal of clinical and experimental hepatology · 2013Article
- Association of laboratory parameters with viral factors in patients with hepatitis C.Virology journal · 2011Article
- HCV genotype-specific correlation with serum markers: higher predictability for genotype 4a.Virology journal · 2011Article
- Response of combination therapy on viral load and disease severity in chronic hepatitis C.Digestive diseases and sciences · 2008Article
- Influence of quasispecies on virological responses and disease severity in patients with chronic hepatitis C.World journal of gastroenterology · 2008Article
- Replicative homeostasis III: implications for antiviral therapy and mechanisms of response and non-response.Virology journal · 2007Article
- Intrahepatic hepatitis C virus replication correlates with chronic hepatitis C disease severity in vivo.Journal of virology · 2006Article
- Hepatitis C virus infection in infants and children from Argentina.Journal of clinical microbiology · 2004Article
- Dynamics of hepatitis C virus replication in human liver.The American journal of pathology · 2003Article
- Quantification of hepatitis C virus in human liver and serum samples by using LightCycler reverse transcriptase PCR.Journal of clinical microbiology · 2002Article
- Comparison of serum hepatitis C virus RNA and core antigen concentrations and determination of whether levels are associated with liver histology or affected by specimen storage time.Journal of clinical microbiology · 2002Article
- Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model.Journal of virology · 2002Article
- Comparison of hepatitis C viral loads in patients with or without human immunodeficiency virus.Clinical and diagnostic laboratory immunology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver disease in chronic hepatitis C virus (HCV) infection ranges from minimal lesions to liver cirrhosis, eventually evolving to hepatocellular carcinoma. Whether and how HCV determines the different clinical and histological manifestations of the disease is not fully understood.
aimsTo verify whether the amount of virus in individual patients could be related to the severity of liver injury. PATIENTS AND
methodsLevels of HCV RNA were measured in serum in 96 consecutive patients with chronic hepatitis type C using a signal amplification assay. The relation between viraemic values and the corresponding viral load in the liver was assessed in a subgroup of 21 patients in whom HCV RNA was measured in serum samples and liver specimens obtained at the same time.
resultsA positive correlation was observed between the amount of viral nucleic acid in the two compartments, indicating that levels of viraemia reflect the amount of virus present in the liver. Viral load did not correlate with aminotransferase activities nor with histological diagnosis, and serum and liver levels of HCV RNA were not significantly different in patients infected by the various HCV genotypes.
conclusionsMeasurement of HCV replication in serum is a mirror of viral replication in the liver. The extent of replicative activity of HCV does not seem to play a role in the modulation of the associated hepatic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.