ArticleGut1998
Oxidative stress: an important phenomenon with pathogenetic significance in the progression of acute pancreatitis.
Article in Gut, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review of Role of Oxidative Stress and Clinical Implications in Acute Pancreatitis.World journal of surgery · 2026Pooled it
- Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders.Nature communications · 2019Trial
- N-acetylcysteine does not prevent post-endoscopic retrograde cholangiopancreatography hyperamylasemia and acute pancreatitis.World journal of gastroenterology · 2006Trial
- Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2006Trial
- Therapeutic efficacy of high-dose vitamin C on acute pancreatitis and its potential mechanisms.World journal of gastroenterology · 2003Trial
- [Effect of preventive selenium administration on development of ERCP-induced acute pancreatitis].Medizinische Klinik (Munich, Germany : 1983) · 1999Trial
- Safety and efficacy of vitamin-based antioxidant therapy in patients with severe acute pancreatitis: a randomized controlled trial.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationTrial
- Oxidative stress in acute pancreatitis induced acute lung injury: mechanisms and therapeutic advances.PeerJ · 2026Review
- Modulating Macrophage Polarization for Severe Acute Pancreatitis Therapy via Cisplatin-like Prussian Blue Nanozymes.Theranostics · 2025Article
- S100A11 Promotes Acute Pancreatitis by Upregulating Acinar Cell Ferroptosis.Mediators of inflammation · 2025Article
- Protective Effect of Naringin in L-arginine-induced Acute Pancreatitis in Wistar Rats.Galen medical journal · 2024Article
- Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis.Autophagy · 2023Article
- Treatment withLife (Basel, Switzerland) · 2023Article
- Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis.Antioxidants (Basel, Switzerland) · 2022Article
- Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis.Journal of veterinary internal medicine · 2022Article
- Ginsenoside Rg3 ameliorates acute pancreatitis by activating the NRF2/HO‑1‑mediated ferroptosis pathway.International journal of molecular medicine · 2022Article
- Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review).Experimental and therapeutic medicine · 2022Review
- Transcriptomics and Network Pharmacology Reveal the Protective Effect of Chaiqin Chengqi Decoction on Obesity-Related Alcohol-Induced Acute PancreatitisFrontiers in pharmacology · 2022Article
- Sulfiredoxin-1 attenuates injury and inflammation in acute pancreatitis through the ROS/ER stress/Cathepsin B axis.Cell death & disease · 2021Article
- Sleep deprivation induces oxidative stress in the liver and pancreas in young and aging rats.Heliyon · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReactive oxygen species and related oxidative damage have been implicated in the initiation of acute pancreatitis. Changes in these parameters during disease progression merit further investigation.
aimsTo evaluate changes and the clinical relevance of superoxide radicals, endogenous antioxidants, and lipid peroxidation during the course of acute pancreatitis. PATIENTS AND
methodsSuperoxide radicals (measured as lucigenin amplified chemiluminescence), ascorbic acid, dehydroascorbic acid, alpha tocopherol, and lipid peroxidation (measured as thiobarbiturate reactive substances) were analysed in blood samples from 56 healthy subjects, 30 patients with mild acute pancreatitis, and 23 patients with severe acute pancreatitis. The association with grades of disease severity was analysed. Measurements were repeated one and two weeks after onset of pancreatitis.
resultsIn the blood from patients with acute pancreatitis, there were increased levels of the superoxide radical as well as lipid peroxides. There was notable depletion of ascorbic acid and an increased fraction of dehydroascorbic acid. Changes in alpha tocopherol were not great except in one case with poor prognosis. Differences between severe and mild acute pancreatitis were significant (p < 0.01). Variable but significant correlations with disease severity scores were found for most of these markers. The normalisation of these indexes postdated clinical recovery one or two weeks after onset of disease.
conclusionsHeightened oxidative stress appears early in the course of acute pancreatitis and lasts longer than the clinical manifestations. The dependence of disease severity on the imbalance between oxidants and natural defences suggests that oxidative stress may have a pivotal role in the progression of pancreatitis and may provide a target for treatment.
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